Alzheimer's Disease

Gene Yields Insights Into The Causes Of Neurodegeneration

Cornell researchers including Fenghua Hu, associate professor in the Department of Molecular Biology and Genetics and member of the Weill Institute for Cell and Molecular Biology, are taking a closer look at the factors that cause Alzheimer's, FTLD...
Related topics: Genetics, Medical Research

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Ethics Consult: Test Alzheimer Drug In Down Syndrome Patients?

(MedPage Today) -- You make the call

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Still No Clear Answer On Intranasal Insulin For Mci, Alzheimer's

A new multicenter trial has yielded conflicting results regarding intranasal insulin's ability to deliver cognitive and functional benefit in mild cognitive impairment and Alzheimer's disease. Medscape Medical News
Related topics: Insulin

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In Alzheimer's Disease, It's Not Always Memory That Goes

Will defining 'dysexecutive' Alzheimer's disease lead to earlier diagnosis and better outcomes in this subtype? Editorial director Bret Stetka talks with Dr David Jones. Medscape Neurology

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Biogen Shares Spike On Alzheimer's Update

The first new drug application for an experimental therapy meant to prevent Alzheimer's disease from worsening finally reached regulators on Wednesday. Biogen (NASDAQ: BIIB) has finally submitted a biologics license application (BLA) for aducanumab,...
Related topics: Nasdaq

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Brain Function In Unresponsive Covid-19; Down Syndrome Patients In Alzheimer's Trials?

(MedPage Today) -- Despite prolonged unresponsiveness and structural brain injury, a 47-year-old patient with severe COVID-19 showed intact brain network function and eventually was able to follow commands. (Annals of Neurology) Iron concentration...
Related topics: Brain Injury

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Researchers Study Effects Of Cellular Crowding On The Cell's Transport System

As many diseases, including neurodegenerative diseases such as Alzheimer's, have been linked to the defective functioning of motor proteins in cell transport systems, understanding the intricacies of how motor proteins work in their native crowded...
Related topics: Medical Research, Proteins

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Inflammatory Bowel Disease Tied To Increased Dementia Risk

Those with Crohn’s disease or ulcerative colitis had higher rates of Alzheimer’s disease and other forms of dementia.
Related topics: Crohn's Disease, Dementia, Ulcerative Colitis

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Why Memory-forming Neurons Are Vulnerable To Alzheimer's

Scientists have used advanced technology to 'micro-dissect' the first brain cells to perish in Alzheimer's disease. The result is a short list of genes that could represent new drug targets.
Related topics: Neurons, Genetics

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Brain's Iron Stores May Be Key To Alzheimer's

TUESDAY, June 30, 2020 -- The progression of Alzheimer's disease may accelerate as iron deposits build up in the brain, a new study finds, hinting at a possible role for the mineral in mental decline. Using MRI scans of 200 older adults with and...
Related topics: Medical Research

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Brain Iron Accumulation Linked To Cognitive Decline In Alzheimer’s Patients

Researchers using MRI have found that iron accumulation in the outer layer of the brain is associated with cognitive deterioration in people with Alzheimer’s disease, according to a study published in the journal Radiology....
Related topics: Medical Research

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Drinking And Thinking; Dementia Deaths Surge; Alzheimer's At Age 48

(MedPage Today) -- Low to moderate alcohol drinking in middle-age or older adults was associated with better global cognition scores. (JAMA Network Open) Repetitive head impacts and traumatic brain injury independently contributed to worse...
Related topics: Dementia, Alcohol, Brain Injury, Depression

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Hormones May Explain Greater Prevalence Of Alzheimer's In Women

FRIDAY, June 26, 2020 -- Women have more Alzheimer's disease-related changes in the brain than men, and this may be linked to hormonal disruptions at menopause, researchers say. "About two-thirds of people living with Alzheimer's are women, and...
Related topics: Hormones, Menopause, Medical Research

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Templating S100a9 Amyloids On Aβ Fibrillar Surfaces Revealed

A research team lead by Ludmilla Morozova Roche at Umeå University, Sweden, has provided the mechanistic insight into protein co-aggregation in Alzheimer's disease. The templating mechanism of S100A9 amyloids on Aβ fibrillar surfaces during...
Related topics: Medical Research, Proteins

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Taiwan Study Ties Ibd To Dementia

(MedPage Today) -- Inflammatory bowel disease (IBD) was associated with more than double the risk of dementia, particularly Alzheimer disease, a Taiwan population study found. Furthermore, individuals with IBD were diagnosed with dementia an...
Related topics: Medical Research, Dementia

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Could Repetitive Negative Thinking Predict Alzheimer's Disease Risk?

(MedPage Today) -- Study Authors: Natalie L. Marchant, Lise R. Lovland, et al. Target Audience and Goal Statement: Neurologists, psychiatrists The goal of this study was to examine the associations of repetitive negative thinking and markers...
Related topics: Medical Research

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Diagnostic Confusion Cleared? Early Alzheimer's Subtype Defined

Patients with progressive dysexecutive syndrome are often initially misdiagnosed, with everything from a psychiatric disorder or frontotemporal dementia to arsenic poisoning or traumatic brain injury. Medscape Medical News
Related topics: Dementia, Arsenic, Poisoning, Brain Injury

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Covid-19 Brain Patterns; Alzheimer's Insulin Trial; Inside Insys

(MedPage Today) -- Brain MRI findings of French patients with severe COVID-19 and without ischemic infarcts followed eight distinctive patterns, with 43% of scans showing signal abnormalities in the medial temporal lobe. (Radiology) Emergency...
Related topics: Insulin

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Five Healthy Choices Tied To Dramatic Cut In Dementia Risk

Data from two longitudinal studies show 60% lower risk for Alzheimer dementia in individuals who practice four of five healthy lifestyle factors. Medscape Medical News
Related topics: Dementia

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Covid-19 Deaths Pass Annual Alzheimer’s Deaths

COVID-19 deaths in America have hit 121,766 so far this year, more than the number of Alzheimer’s deaths over the course of a full year.

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