Enzymes

Study Identifies Enzymes That Prevent Diabetic Kidney Disease

BOSTON -- (May 13, 2019) -- A new study from Joslin Diabetes Center has proven that certain biological protective factors play a large role in preventing diabetic kidney disease in certain people. The study was published today in Diabetes Care. This...
Related topics: Medical Research, Diabetes, Kidney Disease

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Enzyme May Represent New Target For Treating Asthma

An enzyme called diacylglycerol kinase zeta (DGKζ) appears to play an important role in suppressing runaway inflammation in asthma and may represent a novel therapeutic target,
Related topics: Asthma

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How Host-cell Enzymes Combat The Coronavirus

Host-cell enzymes called PARP12 and PARP14 are important for inhibiting mutant forms of a coronavirus, according to a study published May 16 in the open-access journal PLOS Pathogens by Stanley Perlman of the University of Iowa, Anthony Fehr of the...
Related topics: Medical Research

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Enzyme Phlpp2 Could Be A Viable Drug Target For Treating Prostate Cancer

Researchers propose a new druggable target that can put a damper on the spread of prostate cancer. Containing the threat at its origin organ greatly increases the survival rates of patients who suffer from the disease.
Related topics: Prostate Cancer, Cancer, Oncology, Medical Research

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Engineered 'smart Cells' Improve Production Of Pharmaceutical Raw Materials

Researchers in Japan have developed an integrated synthetic biology system to construct new metabolic pathways and enzymes within microbes. By incorporating a "Design, Build, Test, Learn" (DBTL) workflow, the production of pharmaceutical raw...
Related topics: Medical Research

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Link Between Starch Digestion Gene, Gut Bacteria

A newly discovered relationship between genetic variation and the gut microbiome could help nutritionists personalize their recommendations. People with a high number of copies of a gene called AMY1, which expresses a salivary enzyme for breaking...
Related topics: Genetics, Bacteria, Medical Research, Microbiome

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Screening For Genes To Improve Protein Production In Yeast

By silencing genes, researchers have managed to increase protein production in yeast significantly. This method can lay the grounds for engineering better yeast production hosts for industries producing biopharmaceutical proteins and industrial...
Related topics: Genetics, Proteins, Medical Research

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Tailor-made Enzymatic Solutions Reduce Time And Cost Of Biorefinery Processes

Non-food, woody materials (namely lignocellulosic biomass) is the largest renewable reservoir of fermentable starches to substitute fossil fuels. It can be used to produce bio-based polymers and materials for any kind of product – from yoga mats...

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Chemical Probes Pave The Way For A Better Understanding Of Disease Development

Proteins produced in cells often undergo modifications by enzymes after they are formed. One type of modification, called prenylation, adds 'tags' to proteins that tells them where to go in the cell and how to interact with other proteins.
Related topics: Proteins

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Biochemical Switches Identified That Could Be Triggered To Treat Muscle, Brain Disorders

Scientists have found that the enzymes ULK1 and ULK2 play a key role in breaking down cell structures called stress granules, whose persistence leads to toxic buildup of proteins that kill muscle and brain cells. Such buildup is central to the...
Related topics: Stress, Proteins

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Half-hearted: New Insight Into Why The Heart Doesn't Develop Properly In Some Children

Investigators have found evidence that the gene Ccdc117 supports the rapid growth of precursor cells needed for proper development of right-sided heart structures. It does so by promoting transfer of iron-sulfur compounds to enzymes crucial for DNA...
Related topics: Genetics, DNA

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Everyday Enzymes, Now Grown In Plants

Whether we know it or not, enzymes play a role in a range of everyday products, from orange juice to denim jeans. Using his innovative plant-based platform and a new startup company, researchers are transforming how these enzymes are made, resulting...
Related topics: Startup, Medical Research

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Specialist Enzymes Make E. Coli Antibiotic Resistant At Low ph

Scientists long puzzled over why bacteria contain so many "redundant" enzymes. Why make several molecules that do the same job, interchangeably, when it would be much more efficient to make just one?
Related topics: Antibiotics, Bacteria

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Genes Linked With The Most Common Liver Cancer

Researchers have provided the first summary of the experimental evidence supporting the AKR1B10 enzyme as a promising therapeutic target for Hepatocellular carcinoma (HCC), based on a review of more than 50 studies published since this gene was...
Related topics: Genetics, Liver Cancer, Cancer, Oncology, Medical Research, Hepatocellular Carcinoma

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Vitamin B12 Is Identified As The Inhibitor Of A Key Enzyme In Hereditary Parkinson's Disease

Parkinson's is the most common, chronic neurodegenerative movement disorder affecting 1% of the global population over seventy years of age. Right now, there is no cure for this disease and the available treatments focus on addressing its symptoms...
Related topics: Vitamins, Parkinson's

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Structure Of The Molecular Machine That Links Carbohydrate And Lipid Metabolism

A research team has unraveled the three-dimensional structure and molecular mechanism of ATP citrate lyase (ACLY). This is a central metabolic enzyme -- a protein that accelerates chemical reactions -- important for the production of fatty acids and...
Related topics: Medical Research, Proteins

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Stabilizing Ends Of Chromosomes Could Treat Age-related Disease

A study has uncovered a new strategy that can potentially treat age-related disease and decline. The report shows that restoring the activity of a class of enzymes called sirtuins with a small compound stabilized telomeres and reduced DNA damage,...
Related topics: Genetics, Chromosomes, Medical Research, DNA

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Crop Damage: Researchers Advance Effort To Manage Parasitic Roundworms

Roundworms that feed on plants cause approximately $100 billion in annual global crop damage. Now researchers have made a patent-pending discovery that certain enzymes in roundworms, called nematodes, behave differently than the same enzymes in...
Related topics: Medical Research, Patents

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Anti-aging Study Finds Blocking Enzyme Increases Worm Lifespan By 45%

Though humans haven’t yet discovered the fountain of youth, many researchers have been busy trying to solve the puzzle behind aging. One of the newest studies published on the topic has detailed research that successfully extended a...
Related topics: Medical Research

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Discovery Of Life-extension Pathway In Worms Demonstrates New Way To Study Aging

An enzyme-blocking molecule can extend the lifespan of Caenorhabditis elegans roundworms by as much as 45 percent, largely by modulating a cannabinoid biological pathway, according to a new study.
Related topics: Medical Research

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