Enzymes

Bacteria Use Enzymes To Defuse The Immune System

These enzymes are of use to bacteria in two very different ways: to obtain food and to protect them from your body's immune system. Dr. Fatemeh Askarian at NMBU has discovered that these enzymes promote the ability of multi-drug resistance bacteria...
Related topics: Bacteria, Medical Research

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Fund Coronavirus Research, Not A Climate Change Musical

I’ve been a science nerd almost all my life. In graduate school, I was the co-discoverer of a bacterial enzyme essential to DNA replication and of a key enzyme in the influenza virus. I have written more than a thousand articles concerned with...
Related topics: Medical Research, Bacteria, DNA, Genetics, Influenza (Flu), Virus, Virology

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New Data About Sars-cov-2 Virus Functions Could Aid In Treatment Designs

For the first time, a team of researchers has captured X-ray images of a critical enzyme of the COVID-19 virus performing its function. This discovery could improve design of new treatments against the disease.
Related topics: Virus, Virology, Medical Research

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Scientists Reveal Elusive Inner Workings Of Antioxidant Enzyme With Therapeutic Potential

The enzyme manganese superoxide dismutase (MnSOD) plays a critical role in maintaining human health by keeping the amount of harmful reactive oxygen molecules in cells under control. By using neutron scattering, researchers have now obtained a...
Related topics: Medical Research

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Researchers Reveal Elusive Inner Workings Of Antioxidant Enzyme With Therapeutic Potential

Mitochondria, known as the powerhouses within human cells, generate the energy needed for cell survival. However, as a byproduct of this process, mitochondria also produce reactive oxygen species (ROS). At high enough concentrations, ROS cause...
Related topics: Medical Research

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Experimental Therapy For Parasitic Heart Disease May Also Help Stop Covid-19

Researchers found that the chemical inhibitor K777 reduces the coronavirus' ability to infect cell lines by blocking human enzyme cathepsin L; clinical trials are underway.
Related topics: Cardiovascular Disease, Medical Research, Clinical Trials

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A Clue To How Some Fast-growing Tumors Hide In Plain Sight

Viruses churn out genetic material in parts of the cell where it's not supposed to be. Cancer cells do too. A new study shows that a tumor-suppressor enzyme called DAPK3 is an essential component of a multi-protein system that senses misplaced...
Related topics: Cancer, Virus, Virology, Genetics, Oncology, Medical Research, Proteins

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Neutrons Reveal Unpredicted Binding Between Sars-cov-2, Hepatitis C Antiviral Drug

Researchers used neutron scattering to investigate the interactions between telaprevir, a drug used to treat hepatitis C viral infection, and the SARS-CoV-2 main protease, the enzyme responsible for enabling the virus to reproduce. Unforeseen...
Related topics: Viral Hepatitis, Hepatitis, Hepatitis C, Medical Research, Virus, Virology

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Deactivating Cancer Cell Gene Boosts Immunotherapy For Head And Neck Cancers

By targeting an enzyme that plays a key role in head and neck cancer cells, researchers from the UCLA School of Dentistry were able to significantly slow the growth and spread of tumors in mice and enhance the effectiveness of an immunotherapy to...
Related topics: Cancer, Oncology, Genetics, Medical Research

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To Produce More Food, Scientists Look To Get More Mileage Out Of Plant Enzymes

Enzymes play essential roles in the cells of every living thing, from bacteria, to plants to people. Some do their jobs a few times and fizzle out. Others can repeat a task hundreds of thousands of times before they quit.
Related topics: Bacteria

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How Rna Editing Affects The Immune System

Researchers offer new insight into how the immune system relates to cancer. A new articl looks at how an enzyme called ADAR1 operates in pathways associated with cancer.
Related topics: Genetics, Medical Research, Cancer, Oncology

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One Enzyme Dictates Cells’ Response To A Probable Carcinogen

In the past few years, several medications have been found to be contaminated with NDMA, a probable carcinogen. This chemical, which has also been found at Superfund sites and in some cases has spread to drinking water supplies, causes DNA damage...
Related topics: Cancer, DNA, Genetics

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New Proteins 'out Of Nothing'

Proteins are the key component in all modern forms of life. Hemoglobin, for example, transports the oxygen in our blood; photosynthesis proteins in the leaves of plants convert sunlight into energy; and fungal enzymes help us to brew beer and bake...
Related topics: Proteins

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Revealing The Way A Critical Enzyme Works In The Cell

S-acylation is the process of chemically linking a lipid to protein via a thioester bond. It is an important process of the cell that regulates the localization and function of numerous proteins. It promotes lipid membrane association of the...
Related topics: Proteins

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Key Enzymes For Synthesizing Natural Products

Plants, fungi and bacteria produce natural products that function as defenses that are deployed against predators and competitors. In medicine, these compounds have such applications as antibiotics, cancer drugs and cholesterol reducers. The team...
Related topics: Bacteria, Antibiotics, Cancer, Oncology, Cholesterol

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Researchers Discover Sars-cov-2 Inhibitors

A research team of pharmacists at the University of Bonn has discovered two families of active substances that can block the replication of the SARS-CoV-2 coronavirus. The drug candidates are able to switch off the the key enzyme of the virus, the...
Related topics: Medical Research, Virus, Virology

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Novel Drug Prevents Amyloid Plaques, A Hallmark Of Alzheimer's Disease

Researchers have identified a new drug that could prevent AD by modulating, rather than inhibiting, a key enzyme involved in forming amyloid plaques.
Related topics: Alzheimer's Disease, Medical Research

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Price Controls Are Not The Solution For Expensive Insulin

A collection of insulin vials. Insulin is an enzymatic injection that Type 1 and some Type 2 diabetics require on a daily basis to live. Between 1996-2018, insulin prices rose by 1,200%, while production costs remained static, according to a study...
Related topics: Insulin, Diabetes, Medical Research

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Study Uses Crispr/cas9-mediated Gene Editing To Study Function Of Insect Salivary Enzyme

Like a scene from a horror movie, tomato fruitworm caterpillars silence their food plants' cries for help as they devour their leaves. That is the finding of a multidisciplinary team of researchers, who said the results may yield insights into the...
Related topics: Medical Research, Genetics

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Unlocking The Mystery Behind Skeletal Aging

Researchers have identified the role a critical enzyme plays in skeletal aging and bone loss, putting them one step closer to understanding the complex biological mechanisms that lead to osteoporosis, the bone disease that afflicts some 200 million...
Related topics: Medical Research, Osteoporosis

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