Enzymes

Restoring This Enzyme's Function Protects Against Heart Disease In Lupus And Beyond

Patients with lupus are at increased risk of heart disease. Exposing endothelial cells -- known to protect against heart disease, in part by producing nitric oxide -- to the serum of patients with lupus decreased nitric oxide production....
Related topics: Cardiovascular Disease, Lupus, Nitric Oxide

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Plant Immunity Cut To Size

An international team has found a link between a class of enzymes and immune signals that is rapidly triggered upon physical damage in plants. This new discovery will increase our understanding of the plant immune system and might be exploited to...
Related topics: Medical Research

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Crispr/cas Libraries Open New Avenues In Cancer Research

CRISPR/Cas enables the targeted deactivation of genes by cutting DNA at pre-determined sites. This is accomplished by providing the Cas enzyme with a genetic zip code. Using an entire library of zip codes, it is then possible to simultaneously probe...
Related topics: Cancer, Oncology, Medical Research, Genetics, DNA

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Neutrons Paint Atomic Portrait Of Prototypical Cell Signaling Enzyme

Direct observations of the structure and catalytic mechanism of a prototypical kinase enzyme—protein kinase A or PKA—will provide researchers and drug developers with significantly enhanced abilities to understand and treat fatal diseases and...
Related topics: Proteins, Medical Research

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Inflammation Inhibitor Blocks Neurodevelopmental Disorders In Mouse Model

New work shows that an enzyme inhibitor reduced inflammation in the brains of mice born to mothers with maternal immune activation. Inflammation triggered by the enzyme, soluble epoxide hydrolase, is linked to neurodevelopmental disorders in these...

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Enzyme Usp15 May Have Potential Role In Future Treatment Of Various Cancers

A team has found that the deubiquitinating enzyme USP15 is a potential biomarker for treatments of pancreatic cancer, as well as ovarian and breast cancers.
Related topics: Breast Cancer, Cancer, Ovarian Cancer, Pancreatic Cancer, Oncology

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Are There “sleeper” Vaccine-caused Mutations Cytochrome P450 Genes Produce Which Medicine...

Read the full article by Catherine Frompovitch at NaturalBlaze Abstract The human cytochrome P450 (CYP) superfamily comprises 57 genes. These genes code for enzymes that can have a role in: metabolism of drugs, foreign chemicals, arachidonic acid...
Related topics: Vaccines, Genetics

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Promising Strategy To Fight The Most Deadly Brain Tumor In Children

A study found that an inhibitor of an enzyme called ACVR1 slows tumor growth and increases survival in an animal model of diffuse intrinsic pontine glioma (DIPG) -- the most deadly brain tumor in children.
Related topics: Brain Tumors, Cancer, Medical Research

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How Close Does A Gut-on-a-chip Resemble Our Gut?

Maybe, the first question we should ask is, what is a gut comprised of? Gut is a surprisingly complex organ. Within it, is a space where enzyme is produced and secreted, food is digested, nutrients are absorbed and the remaining content is being...

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Yeast Produce Low-cost, High-quality Cannabinoids

Synthetic biologists have created an enzymatic network in yeast that turns sugar into cannabinoids, including tetrahydrocannabinol and cannabidiol, but also novel cannabinoids not found in the marijuana plant itself. The yeast factories would be...

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The Smell Of Food Controls Cellular Recycling And Affects Life Expectancy

The smell of food induces a variety of physiological processes in our body. Thus, the production of saliva and digestive enzymes is stimulated before the actual food intake in order to prepare the gastrointestinal tract for the upcoming digestive...

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Investigators Figure Out How To Block New Antibiotic Resistance Gene

A new antimicrobial-resistance gene, VCC-1, a ß-lactamase gene, has been discovered in benign close relatives of virulent Vibrio cholerae, which causes cholera. Now, a team of Canadian researchers has found a way to block the VCC-1 enzyme, which...
Related topics: Antibiotics, Genetics, Medical Research, Cholera

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Design Principles For Peroxidase-mimicking Nanozymes

Nanozymes, enzyme-like catalytic nanomaterials, are considered to be the next generation of enzyme mimics because they not only overcome natural enzymes' intrinsic limitations, but also possess unique properties in comparison with conventional...

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Why Too Much Dna Repair Can Injure Tissue

Researchers have discovered how overactive DNA repair systems can lead to retinal damage and blindness in mice. A DNA repair enzyme called Aag glycosylase becomes hyperactive, provoking an inflammatory response that produces necrosis, leading to...
Related topics: DNA, Genetics, Medical Research, Blindness, Ophthalmology

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Infection Biology: What Makes Helicobacter So Adaptable?

The bacterial pathogen Helicobacter pylori owes its worldwide distribution to its genetic adaptability. Microbiologists have identified an enzyme that plays a vital role in the flexible control of global gene expression in the species.
Related topics: Helicobacter Pylori, Bacteria, Genetics

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New Target Could Help Protect Vision Following Optic Nerve Trauma

When a car crash or explosion results in an optic nerve injury, eliminating an enzyme known to promote inflammation appears to aid recovery, scientists report.

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How Microbes Produce Key Compound Used To Fight Cancer

Researchers have untangled how bacteria found in soil are able to manufacture streptozotocin, showing for the first time that the compound is produced through an enzymatic pathway and revealing the novel chemistry that drives the process.
Related topics: Cancer, Oncology, Medical Research, Bacteria

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Antidepressants Can Interfere With Pain Relief Of Common Opioids

Some antidepressants inhibit a liver enzyme that converts common opioids into their active form. The interaction may reduce the effectiveness of certain opioids for people taking both medicines. (Image credit: Daniela Jovanovska-Hristovska/Getty...
Related topics: Depression, Antidepressants

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Novel Enzyme Discovered In Intestinal Bacteria

The human intestinal system contains a complex community of microorganisms, the intestinal microbiome, which metabolizes food components that have not readily been digested. However, there are also microbial degradation processes occurring in the...
Related topics: Medical Research, Bacteria, Microbiome

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Medical News Today: Could Targeting This Enzyme Slow Aging And Related Diseases?

In showing how an enzyme halts cell division by producing reactive oxygen species, scientists shed new light on the biology of aging and related diseases.

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