Enzymes

Glycans In The Sars-cov-2 Spike Protein Play Active Role In Infection

Many efforts to develop vaccines and therapies to thwart SARS-CoV-2 focus on the coronavirus spike protein, which binds the angiotensin-converting enzyme 2 (ACE2) on human cells to allow viral entry. Now, researchers have uncovered an active role...
Related topics: Proteins, Vaccines, Medical Research

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Building Bridges: Parp Enzymes Bring Broken Dna Together

Researchers capture the structure of PARP enzymes at work, leading to a new understanding of DNA repair that may aid cancer treatments targeting the process.
Related topics: DNA, Genetics, Medical Research, Cancer, Oncology

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How Dividing Cells Avoid Setting Off False Virus Alarms

One feature of cell division has long puzzled scientists. The nucleus briefly disappears, leaving the cell's DNA exposed. Normally, bare DNA indicates a viral infection and triggers enzymatic alarms that alert the immune system to the rogue DNA. But...
Related topics: Virus, Virology, DNA, Genetics

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Why It's Okay To Eat The Brown Part Of An Avocado

Avocados, like apples, turn brown when exposed to air. It's actually a chemical reaction and not a sign of spoiled avocado. Compounds in the flesh are reacting with oxygen, with the help of enzymes, to produce brown pigments called melanin. The...

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Drugging The Undruggable: Treatment Path For Muscular Dystrophy

Researchers have identified a possible treatment for Duchenne muscular dystrophy (DMD), a rare genetic disease for which there is currently no cure or treatment, by targeting an enzyme that had been considered 'undruggable.'
Related topics: Muscular Dystrophy, Duchenne Muscular Dystrophy, Medical Research, Genetics

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How Cgas Enzyme Is Kept Bottled Up

In higher organisms, detection of DNA in the cytoplasm triggers an immune reaction. The enzyme that senses "misplaced" DNA is also found in the nucleus, but nuclear DNA has no such effect. LMU researchers now report why that is so.
Related topics: DNA, Genetics, Medical Research

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Researchers Draw More Links Between Vaping, Smoking, Young People, And Coronavirus

Vapers, smokers, and non-smokers with chronic conditions are all at higher risk for COVID-19. The scientific explanation behind this is complex and not yet certain -- but it may boil down to an enzyme known as ACE2, that lives on the surface of many...
Related topics: Medical Research, Smoking

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Blood Breakdown Product Commandeers Important Enzyme

The hemoglobin in the red blood cells ensures that our body cells receive sufficient oxygen. When the blood pigment is broken down, heme is produced, which in turn can influence the protein cocktail in the blood. Researchers at the University of...
Related topics: Proteins, Medical Research

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Blood Breakdown Product Commandeers Important Enzyme

The hemoglobin in the red blood cells ensures that our body cells receive sufficient oxygen. When the blood pigment is broken down, 'heme' is produced, which in turn can influence the protein cocktail in the blood. Researchers have now discovered in...
Related topics: Proteins, Medical Research

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First Randomised Trial Backs Safety Of Common Heart Drugs In Covid-19 Patients

Heart patients hospitalized with COVID-19 can safely continue taking angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs), according to new research.
Related topics: Medical Research

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Scientists Develop First Drug-like Compounds To Inhibit Elusive Cancer-linked Enzymes

Structural biology techniques helped researchers target the nuclear receptor-binding SET domain family for the first time; its malfunction is associated with several types of cancer.
Related topics: Cancer, Oncology, Medical Research

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Mitochondria Control Cells Using Their Own Complete Fatty Acid Synthesis Machine

It shouldn't be any secret that mitochondria can make their own fatty acids. The enzymes mitochondria use to do it were discovered decades ago. Unfortunately, only a few individuals among the biologically literate masses have come to appreciate this...
Related topics: Medical Research

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Genomic Study Has Discovered Which Animals Can Get Coronavirus

Ethen Kim Lieser Health, The new study, which was published in the Proceedings of the National Academy of Sciences, has found that any animal that has the same enzyme that SARS-CoV-2 uses to infect human beings is also at risk of infection from...
Related topics: Genetics, Genomics, Medical Research

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Re-engineered Enzyme Could Help Reverse Damage From Spinal Cord Injury And Stroke

A team of researchers from University of Toronto Engineering and the University of Michigan has redesigned and enhanced a natural enzyme that shows promise in promoting the regrowth of nerve tissue following injury.
Related topics: Stroke, Medical Research

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Researchers Discover New Information On The Regulation Of Cancer Cell Motility

PIM kinases are enzymes that promote metastatic growth and spread of cancer cells. Researchers from the University of Turku, Finland, have obtained new information on how PIM kinases enhance cancer cell motility by regulating the formation of actin...
Related topics: Medical Research, Cancer, Oncology

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Enzyme Cocktail Developed In Brazil Powers Production Of Second-generation Ethanol

Researchers at the Brazilian Center for Research in Energy and Materials (CNPEM) have genetically engineered a fungus to produce a cocktail of enzymes that break down the carbohydrates in biomass, such as sugarcane trash (tops and leaves) and...
Related topics: Medical Research, Genetics

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Researchers Discover How Enzyme Protects Cells From Dna Damage

A research team from Mount Sinai has unraveled for the first time the three-dimensional structure and mechanism of a complex enzyme that protects cells from constant DNA damage, opening the door to discovery of new therapeutics for the treatment of...
Related topics: Medical Research, DNA, Genetics

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Known Enzyme May Be Key To Unlocking Super Endurance In Humans

A new study from Harvard University details the discovery of a critical role the enzyme prolyl hydroxylase 3 (PHD3) plays that may help lead to super-endurance capabilities in humans. The study, which involved lab mice, involved blocking this...
Related topics: Medical Research, Harvard University

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Bacterial Enzymes Hijacked To Create Complex Molecules Normally Made By Plants

Chemists have efficiently created three families of complex, oxygen-containing molecules that are normally obtainable only from plants. These molecules, called terpenes, are potential starting points for new drugs and other high-value products --...
Related topics: Bacteria

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Flipping A Metabolic Switch To Slow Tumor Growth

The enzyme serine palmitoyl-transferase can be used as a metabolically responsive 'switch' that decreases tumor growth, according to a new study.
Related topics: Cancer, Medical Research

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