Genetics

How A Protein Stops Cells From Attacking Their Own Dna

Viruses multiply by injecting their DNA into a host cell. Once it enters the intracellular fluid, this foreign material triggers a defense mechanism known as the cGAS-STING pathway. The protein cyclic GMP-AMP Synthase (cGAS), which is also found...
Related topics: Proteins, DNA, Virus, Virology

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Busting Up The Infection Cycle Of Hepatitis B

Researchers have gained new understanding of the virus that causes hepatitis B and the 'spiky ball' that encloses its genetic blueprint. They looked at how the capsid -- a protein shell that protects the blueprint and also drives the delivery of it...
Related topics: Hepatitis, Hepatitis B, Medical Research, Virus, Virology, Proteins

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Ancient Genomes Suggest Woolly Rhinos Went Extinct Due To Climate Change, Not Overhunting

Although overhunting led to the demise of some prehistoric megafauna after the last ice age, a new study found that the extinction of the woolly rhinoceros may have been caused by climate change. By sequencing ancient DNA from 14 woolly rhinos,...
Related topics: DNA

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Leukemia Breakthrough: Circasxl1-1 Regulates Bap1 Deubiquitinase Activity In Leukemia

Researchers have identified covalently closed circular RNAs (circRNAs) from key genes involved in leukemia development and provided greater understanding of their roles in haematological malignancies.
Related topics: Leukemia, Medical Research

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Programmed Bacteria Have Something Extra

Chemists expand the genetic code of Escherichia coli bacteria to produce a synthetic building block, a 'noncanonical amino acid' that makes it a living indicator for oxidative stress. The research is a step toward designed cells that detect disease...
Related topics: Bacteria, Stress, Medical Research

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‘momentous News’: Fda Approves Launch Of Phase 1 Trial For Potential Hiv Cure

US biotechnology firm American Gene Technologies (AGT) on Tuesday received approval from the US Food and Drug Administration (FDA) to start a phase-one clinical trial of a potential cure for the human immunodeficiency virus (HIV), which causes...
Related topics: Food And Drug Administration, Clinical Trials, HIV, Virus, Biotechnology, Virology

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Genetic Research May Help Identify Causes Of Stillbirth

WEDNESDAY, Aug. 12, 2020 -- Scientists are well on the way to understanding more about how genes can cause stillbirth, new research suggests. In the study, researchers used genetic analyses to identify gene mutations that are linked to stillbirth,...
Related topics: Medical Research

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Rare Duchenne Muscular Dystrophy Mutation Has New Tx

(MedPage Today) -- WASHINGTON -- Viltolarsen (Viltepso) injection has been approved to treat Duchenne muscular dystrophy (DMD) in patients with a confirmed mutation in the DMD gene amenable to exon 53 skipping, the FDA said Wednesday. About...
Related topics: Duchenne Muscular Dystrophy, Muscular Dystrophy, Food And Drug Administration

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Should We Sequence Newborns’ Dna? The Answer Is Complicated, Study Finds

Many adults seek genetic counseling, or opt to send samples of their saliva to companies like 23andMe, to find out if the specific patterns in their DNA may put them at higher risk for developing disease. But many doctors and scientists —...
Related topics: DNA, Medical Research

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Which Women Choose Hormones For Surgical Menopause?

(MedPage Today) -- Among women with BRCA mutations who underwent preventive oophorectomy, those who were younger, more educated, or had a prophylactic mastectomy were more likely to use hormone therapy to manage adverse effects of surgical...
Related topics: Hormones, Menopause, Mastectomy

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Chemists Expand Genetic Code Of E. Coli To Produce 21st Amino Acid, Giving It New Abilities

Rice University chemist Han Xiao and his team have successfully expanded the genetic code of Escherichia coli bacteria to produce a synthetic building block, a "noncanonical amino acid." The result is a living indicator for oxidative stress.
Related topics: Medical Research, Bacteria, Stress

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Mutations May Have Saved Brown Howlers From Yellow Fever Virus

From 2007 to 2009, a devastating yellow fever virus outbreak nearly decimated brown and black and gold howler monkey populations at El Parque El Piñalito in northeastern Argentina. An international research team tested if howlers who survived the...
Related topics: Virus, Virology, Medical Research

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Wednesday Assorted Links

1. “On November 9th, 2019 the Center for Genomic Gastronomy will install the Smog Tasting project in Hong Kong City Hall.  Citizens will be able to taste and compare a range of smog meringues collected from around the city considering the...
Related topics: Genomics

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Best Dna Test In 2020: 23andme Vs. Ancestrydna And More - Cnet

Looking for the best DNA test kit and the best testing services? Here are your top options.
Related topics: DNA, DNA Test

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Selfish Genes Take Sides In The Battle Of The Sexes

Men may have a surprising genetic advantage over women, according to new research carried out at the University of St Andrews.

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Why Deaf People Oppose Using Gene Editing To "cure" Deafness

Researchers have figured out how to use a gene-editing tool called CRISPR 2.0 to prevent and treat deafness. But many deaf people are happy the way they are.
Related topics: Medical Research

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Scientists Forced To Change Names Of Human Genes Because Of Microsoft's Failure To Patch Excel

Six years ago, Techdirt wrote about a curious issue with Microsoft's Excel. A default date conversion feature was altering the names of genes, because they looked like dates. For example, the tumor suppressor gene DEC1 (Deleted in Esophageal Cancer...
Related topics: Microsoft

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Billion-dollar Parkinson's Deal; Selma Blair's Ms; 'rinsing Of The Brain'

(MedPage Today) -- Biogen will pay more than $1 billion to the biotech firm Denali to co-develop small-molecule drugs targeting LRRK2 gene mutations in Parkinson's disease and to opt into Denali's platform of delivering drugs across the...
Related topics: Parkinson's

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Trump Given Deadline To Submit Dna Samples

President Trump was given a series of deadlines to produce his DNA and other evidence as part of mandatory discovery in an ongoing defamation lawsuit, Law & Crime reports.
Related topics: DNA, Scientific Discoveries, Lawsuits

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For Bacteria, A Small Genome Means Some Serious Decluttering—even In The Ribosome

Researchers from Skoltech, Lomonosov Moscow State University and the Kharkevich Institute for Information Transmission Problems have studied the genomes of some 200 strains of bacteria to determine which proteins in the ribosome, part of the key...
Related topics: Proteins

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