Genetics

Prime Editing The Genome

Move over CRISPR – enter Prime Editing. Maybe. What we can say is that the pace of technological advancement in genetic editing is advancing so quickly it’s hard to keep up. Now a new study, published in Nature, details a new method for...

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New Organelle Discovered Inside Cells Found To Prevent Cancer

Scientists at the University of Virginia School of Medicine have discovered a strange new organelle inside our cells that helps to prevent cancer by ensuring that genetic material is sorted correctly as cells divide.
Related topics: Medical Research, Cancer, Oncology

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Did Archaic Genetic Variants Help Melanesians Adapt?

Compared with other world groups, the DNA of Melanesian populations carries some of the largest percentage of ancestry from now-extinct Neanderthals and Denisovans. A genomic study of Melanesians suggests that certain genetic variants inherited from...
Related topics: DNA, Genomics

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Fda Oks First Triple Combo Therapy For Cystic Fibrosis

Trikafta combines elexacaftor, ivacaftor, and tezacaftor for patients 12 years or older with CF and at least one F508del mutation in the CFTR gene. FDA Approvals
Related topics: Food And Drug Administration, Cystic Fibrosis

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Iolani School Awarded Educational Leadership Grant For Science Program

Iolani School was awarded a 2019 Educational Leadership Grant from the Edward E. Ford Foundation for its genomic and bioethics program, the school announced Monday. The $182,200 grant will support the school's Aina-Informatics Network — or AIN...
Related topics: Ford, Genomics

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Here’s Why Seattle Genetics Climbed Higher Today

Shares of Seattle Genetics (NASDAQ: SGEN) are up 15% at 11:55 a.m. EDT after the biotech reported positive results for the HER2CLIMB phase 2 study testing tucatinib in patients with late-stage breast cancer.Treatment with tucatinib plus Roche's...
Related topics: Nasdaq, Medical Research, Breast Cancer, Cancer, Oncology

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Scientists Laid Out A Technological Roadmap For What They'll Need To Write Synthetic Genomes From...

An artist's representation of big data applied to DNA. (Credit: Zita/Shutterstock) At first, it was just Mendel and some pea plants. In the 150 years that followed, matching pairs of chromosomes were labeled, As, Ts Cs and Gs were coupled off...
Related topics: DNA, Chromosomes

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The Ftc Has Confirmed That Sunday Riley Faked Product Reviews

Sunday Riley, the maker of the cult—and extremely pricey—skincare product Good Genes, has been found by the Federal Trade Commission to have misled its customers “by posting fake reviews of the company’s products on a major retailer’s...

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New Gene-editing Tool Could Fix Genetic Defects--with Fewer Unwanted Effects

“Prime editing” can potentially correct almost any type of mutation, but it requires much more testing before clinical use -- Read more on ScientificAmerican.com

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Man Forced To Pay Child Support Even Though Dna Test Proves Child Is Not His

A Florida man has been forced to pay child support even though a DNA test proved that he is not the child's biological father, First Coast News reports. Read more...
Related topics: DNA, DNA Test

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Uncovering The Principles Behind Rna Folding

A Northwestern Engineering research team led by Professor Julius Lucks has uncovered a new understanding of how RNA molecules act as cellular 'biosensors' to monitor and respond to changes in the environment by controlling gene expression. The...

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Comparisons Of 4.7 Million Mtdna Sequences Show Genbank Is Reliable For Animal Ids

Did a murderer walk through the room? Did a shark just swim by? Is this a poisonous mushroom? Which reef species are lost when the coral dies? These questions can potentially be answered quickly and cheaply based on tiny samples of DNA found in the...
Related topics: DNA

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The Secret Of Classic Belgian Beers? Medieval Super Yeasts!

An international team of scientists has discovered that some of the most renowned classic Belgian beers, including Gueuze and Trappist ales, are fermented with a rare and unusual form of hybrid yeasts. These yeasts combine DNA of the traditional ale...
Related topics: Medical Research, DNA

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This Groundbreaking Dna Tool Could Edit-out Genetic Disease

The DNA-editing tool revealed by researchers today could potentially “fix” the vast majority of known genetic diseases. According to the research text published today, the system of “Prime editing” could potentially...
Related topics: DNA, Medical Research

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Defining The Centromere

Centromeres are the chromosomal domains at which the kinetochore, a protein complex required for the correct separation of chromosomes during mitosis and meiosis, is assembled. The incorporation of the histone variant CenH3 into centromeric...
Related topics: Proteins, Chromosomes

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Unique Brain Changes In People With Huntington's Disease

The part of the brain that selectively degenerates in people with Huntington's disease (HD), called the striatum, is almost entirely destroyed in the late stages of the disease. Brain samples from mutant HD gene positive individuals who had not yet...
Related topics: Huntington Disease

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Gene Variants Influence Size Of Brainstem, Other Structures

Three-hundred researchers have identified 48 common genetic variants that are associated with the size of the brainstem and other subcortical structures deep within the brain. This is the first step toward understanding how to devise treatments for...
Related topics: Medical Research

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How The Mouse X And Y Chromosomes Compete With Each Other To Control Offspring

New research presents the first demonstration of a specific difference in sperm function associated with sex ratio skewing.
Related topics: Chromosomes

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New Crispr Genome Editing System Offers A Wide Range Of Versatility In Human Cells

A team has developed a new CRISPR genome-editing approach by combining two of the most important proteins in molecular biology -- CRISPR-Cas9 and a reverse transcriptase -- into a single machine.
Related topics: Proteins

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Uncovering The Principles Behind Rna Folding

Using high-throughput next-generation sequencing technology, a researcher found similarities in the folding tendencies among a family of RNA molecules called riboswitches, which play a pivotal role in gene expression.

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