Glioblastoma

Epirubicin-loaded Nanomedicines Beat Immune Checkpoint Blockade Resistance In Glioblastoma

A nanomedicine-based strategy for chemo-immunotherapy (CIT) of glioblastoma (GBM), which has the worst prognosis among brain tumors, was successfully developed. In vivo experiments demonstrated that the combined use of epirubicin-encapsulating...
Related topics: Chemotherapy, Cancer, Brain Tumors

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New Drug Targets For Lethal Brain Cancer Discovered

More than 200 genes with novel and known roles in glioblastoma - the most aggressive type of brain cancer - offer promising new drug targets. Researchers engineered a new mouse model to show for the first time how a mutation in the well-known cancer...
Related topics: Brain Tumors, Cancer, Oncology, Medical Research, Genetics

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Scientists Id Gene Responsible For Deadly Glioblastoma

The discovery of the oncogene responsible for glioblastoma could be the brain cancer's Achilles' heel, one researcher says.
Related topics: Genetics, Medical Research, Brain Tumors, Cancer, Oncology

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Breaking Bad News To Patients When They Are Alone [podcast]

“Today, we got called on a patient in the ICU who recently had a new brain mass removed surgically. The specimen came back positive for an aggressive brain tumor known as glioblastoma multiforme. We discussed his diagnosis and prognosis with...
Related topics: Podcasts, Brain Tumors, Cancer

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Did Northwest Biotherapeutics Just Check Off 1 Box Needed For Its Stock To Double?

In April, Northwest Biotherapeutics (OTC: NWBO) disclosed that its phase 3 clinical trial to evaluate its cancer immunotherapy vaccine DCVax-L in treating glioblastoma, the most invasive form of brain cancer, may finally be coming to an end. The...
Related topics: Clinical Trials, Brain Tumors, Cancer, Oncology, Vaccines

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No Os Boost With Opdivo In Recurrent Glioblastoma

]]>(MedPage Today) -- The CheckMate 143 trial of nivolumab (Opdivo) in patients with recurrent glioblastoma failed to meet its primary endpoint versus bevacizumab (Avastin), researchers reported. Among 369 patients with recurrent glioblastoma...
Related topics: Avastin, Medical Research

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Boosting The Immune System's Appetite For Cancer

A combination of immunotherapy agents that encourages some immune cells to eat cancer cells and alert others to attack tumors put mice with a deadly type of brain cancer called glioblastoma into long-term remission.
Related topics: Brain Tumors, Cancer, Oncology

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Breaking Bad News To Patients When They Are Alone

Today, we got called on a patient in the ICU who recently had a new brain mass removed surgically. The specimen came back positive for an aggressive brain tumor known as glioblastoma multiforme. We discussed his diagnosis and prognosis with him at...
Related topics: Brain Tumors, Cancer

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Glioblastoma Study Supports Safe Maximal Tumor Resection

(MedPage Today) -- Study Authors: Annette M. Molinaro, Shawn Hervey-Jumper, et al.; Bryan D. Choi, Elizabeth R. Gerstner, William T. Curry Jr. Target Audience and Goal Statement: Oncologists, neurosurgeons, radiologists The goal of this study...
Related topics: Medical Research, Cancer, Oncology

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Data Favor Max Resection For All Glioblastomas

]]>(MedPage Today) -- Aggressive tumor resection was associated with improved overall survival (OS) for glioblastoma patients and was independent of IDH status, a retrospective study indicated. Resection of contrast-enhanced tumor tissue...
Related topics: Cancer, Medical Research

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Brain Tumor Surgery That Pushes Boundaries Boosts Patients Survival

Survival may more than double for adults with glioblastoma, the most common and deadly type of brain tumor, if neurosurgeons remove the surrounding tissue as aggressively as they remove the cancerous core of the tumor.  This discovery, reported in...
Related topics: Brain Tumors, Cancer, Medical Research

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University Hospitals Seidman Cancer Center Treats Its First Glioblastoma Patient With Genetically...

University Hospitals Seidman Cancer Center treated its first patient in a new clinical trial to validate the groundbreaking effects of the poliovirus on glioblastoma (GBM), a deadly Grade IV cancer of the brain. UH is the only Midwest site...
Related topics: Medical Research, Brain Tumors, Cancer, Oncology, Genetics, Clinical Trials

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A Menu Of Brain Cancer Treatments

Sara Piccirillo, PhD, is passionate about finding a way to beat glioblastoma, the most aggressive type of brain cancer. Her research focuses on a feature of glioblastoma tumors that appears to be the source of their strength: the extreme differences...
Related topics: Brain Tumors, Cancer, Oncology, Medical Research

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International Research Team Confirms Potential Glioblastoma Inhibitors

However, San Diego Supercomputer Center (SDSC) Research Scientist Igor Tsigelny recently collaborated Researchers from the San Diego Supercomputer at UC San Diego and colleagues from Sweden's Karolinska Institute and the Pasteur Institute in France...

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Brain Tumor Organoids May Be Key To Time-sensitive Treatments For Glioblastomas

Lab-grown brain organoids developed from a patient's own glioblastoma, the most aggressive and common form of brain cancer, may hold the answers on how to best treat it. A new study in Cell from researchers at Penn Medicine showed how glioblastoma...
Related topics: Brain Tumors, Cancer, Oncology, Medical Research

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Researchers Identify Immune-suppressing Target In Glioblastoma

Researchers at The University of Texas MD Anderson Cancer Center have identified a tenacious subset of immune macrophages that thwart treatment of glioblastoma with anti-PD-1 checkpoint blockade, elevating a new potential target for treating the...
Related topics: Medical Research, Cancer, Oncology

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Non-coding Dna Located Outside Chromosomes May Help Drive Glioblastoma

According to a new study, extra DNA scooped up and copied alongside cancer-causing genes helps keep tumors going -- elements that could represent new drug targets for brain tumors and other cancers notoriously difficult to treat.
Related topics: DNA, Genetics, Chromosomes, Medical Research, Brain Tumors, Cancer, Oncology

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Potential Drug Targets For Glioblastoma Identified

Researchers have identified 10 tumor-specific potential drug targets for the brain tumor glioblastoma.
Related topics: Medical Research, Brain Tumors, Cancer

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Blood Test Can Predict Prognosis In Deadly Brain Cancer

A blood test that measures the amount of cell-free DNA (cfDNA) in the bloodstream - called a liquid biopsy - correlates with how patients will progress after they are diagnosed with glioblastoma (GBM), the deadliest and most common primary brain...
Related topics: Blood Test, DNA Test, Brain Tumors, Cancer, Oncology, DNA, Genetics, Biopsy

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A Compound Effective To Chemotherapy-resistant Cancer Cells Identified

A compound effective in killing chemotherapy-resistant glioblastoma-initiating cells (GICs) has been identified, raising hopes of producing drugs capable of eradicating refractory tumors with low toxicity.
Related topics: Chemotherapy, Cancer, Oncology

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