Leukemia

Drug Combo Prolongs Survival In Acute Myeloid Leukemia

THURSDAY, Aug. 13, 2020 -- Overall survival is longer and the incidence of remission is higher among previously untreated, older patients with acute myeloid leukemia (AML) who receive azacitidine plus venetoclax versus azacitidine alone, according...

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Leukemia Breakthrough: Circasxl1-1 Regulates Bap1 Deubiquitinase Activity In Leukemia

Researchers have identified covalently closed circular RNAs (circRNAs) from key genes involved in leukemia development and provided greater understanding of their roles in haematological malignancies.
Related topics: Medical Research, Genetics

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Ash Issues Guidelines On Newly Diagnosed Aml In Older Adults

WEDNESDAY, Aug. 12, 2020 -- In evidence-based guidelines issued by the American Society of Hematology and published in the Aug. 11 issue of Blood Advances, recommendations are presented for the management of newly diagnosed acute myeloid leukemia...
Related topics: Hematology

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Aml Guideline Reinforces Individualized Treatment

(MedPage Today) -- Appropriately selected and counseled older patients with acute myeloid leukemia (AML) should receive chemotherapy in preference to supportive care and more-intensive versus less-intensive therapy if they can tolerate it,...
Related topics: Chemotherapy, Cancer

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Resistant Cancer Cells Can Be Targeted For Elimination

Blood cancers, such as leukemia, can be effectively treated with chemotherapy, although relapse usually occurs when resistant cancer cells evade the original drug regimen. Harvard University researchers have identified a unique characteristic of the...
Related topics: Cancer, Oncology, Chemotherapy, Harvard University, Medical Research

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Survivors Of Adolescent, Young Adult All May Suffer Late Effects

FRIDAY, July 31, 2020 -- Survivors of adolescent and young adult (AYA) acute lymphoblastic leukemia (ALL) may experience late effects, with a high incidence of subsequent endocrine disease and cardiac disease, according to a study published in the...
Related topics: Medical Research

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Updated Results On Murano And Ascend In Cll

(MedPage Today) -- At the American Society of Clinical Oncology virtual annual meeting, one abstract measured the impact of premature venetoclax discontinuation/interruption on outcomes in relapsed/refractory chronic lymphocytic leukemia (CLL)...
Related topics: American Society Of Clinical Oncology, Cancer, Oncology

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Fda Approves Oral Treatment For Myelodysplastic Syndrome

WEDNESDAY, July 8, 2020 -- The U.S. Food and Drug Administration has approved Inqovi (decitabine and cedazuridine) tablets, an oral outpatient treatment option for patients with myelodysplastic syndromes and chronic myelomonocytic leukemia, the...
Related topics: Food And Drug Administration

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Fda Oks Oral Drug For Certain Blood Cancers

(MedPage Today) -- WASHINGTON -- The FDA on Tuesday approved an oral formulation of decitabine and cedazuridine (Inqovi) for adults with intermediate- and high-risk myelodysplastic syndromes (MDS) and chronic myelomonocytic leukemia (CMML)....
Related topics: Food And Drug Administration, Oral Cancer, Cancer, Oncology

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Why Mei Pharma Is Tanking 15.3% Today

Shares in MEI Pharma (NASDAQ: MEIP) are tumbling 15.3% at 11:55 a.m. EDT on Thursday following news its collaboration partner, Helsinn Group, is discontinuing a phase 3 trial of pracinostat in acute myeloid leukemia, or AML.Helsinn Group was...
Related topics: Nasdaq

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Incidence Of Vte, Major Bleeding High In Primary Cns Lymphoma

MONDAY, June 29, 2020 -- The incidence of venous thromboembolism (VTE) and major bleeding is high among patients with primary central nervous system lymphoma (PCNSL), according to a study published online June 23 in Leukemia & Lymphoma. Anjlee...
Related topics: Lymphoma, Medical Research

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Engineered Immune Cells Recognize, Attack Human And Mouse Solid-tumor Cancer Cells

CAR-T therapy has been used successfully in patients with blood cancers such as lymphoma and leukemia. It modifies a patient's own T-cells by adding a piece of an antibody that recognizes unique features on the surface of cancer cells. In a new...
Related topics: Cancer, Oncology, Lymphoma, Medical Research

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Treating Leukaemia More Effectively

Acute lymphoblastic leukaemia (ALL) is the most common kind of cancer in children. T-ALL, a subtype that resembles T-lymphocytes, can be treated successfully with the drug nelarabine. The drug has not been successful, however, with B-ALL, a subtype...
Related topics: Cancer, Oncology

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How Can We Stop The Spread Of Coronavirus?

I have chronic lymphocytic leukemia, and I do not want anyone to infect me. Because of my leukemia, I have low immunoglobulin levels, so I am extremely cautious. If I were to become infected, it would mean that I did something to put myself in...

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Neanderthal Dna Used To Grow A 'mini-brain'

Switzerland-based researchers successfully used Neanderthal DNA to grow a brain organoid. The team, led by Grayson Camp, used induced pluripotent stem cells, which are used to research diabetes, leukemia, and neurological disorders.By tracing back...
Related topics: DNA, Genetics, Medical Research, Stem Cells, Diabetes

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Nanoparticle For Overcoming Leukemia Treatment Resistance

One of the largest problems with cancer treatment is the development of resistance to anticancer therapies. A research team found that repurposing a commonly used chemotherapy drug using a nanoparticle was more effective than both a solution of the...
Related topics: Cancer, Oncology, Medical Research, Chemotherapy

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Combination Ups Survival In Older Aml Patients

(MedPage Today) -- Older patients with acute myeloid leukemia (AML) had clinically meaningful improvement in overall survival (OS) when they received the Bcl-2 inhibitor venetoclax (Venclexta) in addition to standard therapy, a randomized trial...

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Three-drug Combo Promising Against High-risk Cll

The combination of obinutuzumab, ibrutinib, and venetoclax was associated with a high complete response rate in patients with high-risk chronic lymphocytic leukemia, a phase 2 trial finds. Medscape Medical News

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What About The Mental Health Of Clinical Trial Participants? 

“Why is my disease less important than COVID?” Donna asked me toward the end of our phone call. Two years ago, after celebrating her 65th birthday, she was diagnosed with acute myeloid leukemia—an aggressive type of blood cancer—which...
Related topics: Clinical Trials, Cancer, Oncology

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Dexrazoxane Preserves Cardiac Function In Pediatric Leukemia

TUESDAY, May 12, 2020 -- For pediatric patients with acute myeloid leukemia (AML), dexrazoxane preserves cardiac function without affecting survival, according to a study published online April 28 in the Journal of Clinical Oncology. Kelly D....
Related topics: Medical Research, Cancer, Oncology

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