Leukemia

Clinical Challenges: Timely Testing For Genetic Mutations In Aml

(MedPage Today) -- Acute myeloid leukemia (AML) is a genetically heterogeneous malignancy characterized by recurrent gene mutations. Genomic heterogeneity, patients' individual variability, and recurrent mutations are major obstacles to optimum...
Related topics: Genetics, Genomics

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Lee Zeldin Has Leukemia

Rep. Lee Zeldin (R-NY), the leading Republican candidate in next year’s race for governor in New York, revealed that he was diagnosed with leukemia last year and has been receiving treatment, the New York Times reports.

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Researchers Identify A Novel Player In Acute Myeloid Leukemia

A new study has shown that the protein RNF5 plays an unusual role in acute myeloid leukemia (AML). Unlike its expected role, marking aberrant proteins for destruction, RNF5 binds with a second cell protein called RBBP4 to control expression of genes...
Related topics: Medical Research, Proteins, Genetics

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Blood Cancer Cures And Care: Addressing Leukemia And Lymphoma

Kevin David, MD the director of the lymphoma program and a hematologist/oncologist at Rutgers Cancer Institute of New Jersey shares information about leukemias and lymphomas for blood cancer awareness month.
Related topics: Cancer, Oncology, Lymphoma, Hematology

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Ibrutinib For Cll Tied To Higher Heart Risks Vs Chemotherapy

(MedPage Today) -- Use of the Bruton tyrosine kinase (BTK) inhibitor ibrutinib (Imbruvica) was linked with cardiovascular risks in patients with chronic lymphocytic leukemia (CLL), according to results of a population-based cohort study. Over...
Related topics: Chemotherapy, Cancer, Cardiology, Medical Research

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Bio-path (bpth) To Begin Clinical Study On Leukemia Drug

Bio-Path Holdings, Inc. BPTH announced that the FDA has cleared its investigational new drug (“IND”) application for BP1002 (liposomal Bcl-2), a novel cancer candidate targeting Bcl-2 Protein. The candidate will be evaluated as a...
Related topics: Medical Research, Food And Drug Administration, Cancer, Oncology, Proteins

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Teaching An Old Dog New Tricks: An Existing Drug Opens New Possibilities For Treating Childhood...

A new study has shown that the tumor-inhibiting gene TET2 is silenced in a large fraction of cases of acute lymphoblastic leukemia (ALL) in children. The scientists show that the gene can be reactivated by treatment with an existing drug,...
Related topics: Medical Research, Cancer, Genetics

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Researchers Uncover Evolutionary Forces At Play In The Aging Of The Blood System And Identify...

Study shows how the interplay of positive, neutral and negative evolutionary selection acting on mutations in aging blood stem cells can lead to acute myeloid leukemia (AML) in some individuals with age-related clonal hematopoiesis (ARCH).
Related topics: Medical Research, Genetics, Stem Cells

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Anti-cd7 Car-t Therapy Yields High Response Rate In Acute Leukemia

(MedPage Today) -- Donor-derived anti-CD7 chimeric antigen receptor (CAR) T-cell therapy led to complete responses in 18 of 20 patients with relapsed or refractory (r/r) T-cell acute lymphoblastic leukemia (ALL), a first-in-human clinical trial...
Related topics: Clinical Trials

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Duration Of Maintenance Therapy Studied In Childhood All

MONDAY, Aug. 2, 2021 -- For patients with low-risk childhood acute lymphoblastic leukemia, the omission of seven pulses of therapy with vincristine and oral dexamethasone during the second year of maintenance therapy might not worsen treatment...

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Add-on Venetoclax Promising In Younger, Fit Aml Patients

(MedPage Today) -- The addition of the BCL-2 inhibitor venetoclax (Venclexta) to intensive chemotherapy was safe and active in patients with newly diagnosed acute myeloid leukemia (AML) or high-risk myelodysplastic syndromes, researchers reported...
Related topics: Chemotherapy, Cancer, Medical Research

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Eliminating Rna-binding Protein Improves Survival In Aggressive Leukemia

Removing a protein that is often overexpressed in a rare and aggressive subtype of leukemia can help to slow the cancer’s development and significantly increase the likelihood of survival, according to a study in mice led by scientists at...
Related topics: Genetics, Proteins, Cancer, Oncology, Medical Research

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Racial Disparities Persist In Multiple Myeloma Care, Outcomes

MONDAY, July 26, 2021 -- There are persistent disparities in multiple myeloma (MM) care for non-Hispanic (NH)-Blacks and Hispanics compared with NH-Whites, according to a study published online July 18 in Leukemia & Lymphoma. Samer Al Hadidi,...
Related topics: Medical Research, Lymphoma

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Chemotherapy Can Induce Mutations That Lead To Pediatric Leukemia Relapse

A collaboration led by St. Jude Children's Research Hospital, Shanghai Children's Medical Center and others revealed how thiopurines produce mutations that lead to multi-drug resistant leukemia and relapse.
Related topics: Chemotherapy, Cancer, Genetics, Medical Research

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Chemotherapy Can Induce Mutations That Lead To Pediatric Leukemia Relapse

A collaboration led by St. Jude Children's Research Hospital, Shanghai Children's Medical Center and others revealed how thiopurines produce mutations that lead to multi-drug resistant leukemia and relapse.
Related topics: Chemotherapy, Cancer, Genetics, Medical Research

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Ibrutinib Effective Treatment For Difficult-to-treat Forms Of Hairy Cell Leukemia, Study Finds

The oral targeted therapy drug ibrutinib is an effective treatment option for high-risk hairy cell leukemia, according to a new study.
Related topics: Medical Research

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New Discoveries Reveal How Acute Myeloid Leukemia Walks A Fine Line Between Growth And Cell Death

Researchers revealed new insights into how acute myeloid leukemia (AML) develops and progresses, according to a study published in Molecular Cell on July 20, 2021. They describe a mechanism by which AML cells regulate a cancer-related protein,...
Related topics: Medical Research, Cancer, Oncology, Proteins

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Unraveling The Mechanisms That Create The Individualized Metabolism In Leukemia

Lysine-specific demethylase 1 (LSD1), an enzyme involved in gene expression, produces individualized metabolism depending on the type of acute myeloid leukemia cells. Cancer cells have a unique ability to metabolize substances differently from...
Related topics: Enzymes, Genetics, Cancer, Oncology

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Jazz Pharma (jazz) Gets Fda Approval For Leukemia Drug Rylaze

Want the latest recommendations from Zacks Investment Research? Today, you can download 7 Best Stocks for the Next 30 Days. Click to get this free report Jazz Pharmaceuticals PLC (JAZZ): Free Stock Analysis Report CanFite Biopharma Ltd...
Related topics: Food And Drug Administration, Medical Research

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Clinical Challenge: Test Your Knowledge On Leukemia

(MedPage Today) -- A three-question quiz on pediatric ALL, AML, and the risks with COVID-19

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