Melanoma

Searching For Biomarkers To Better Guide Melanoma Therapy

Dr Jeffrey Weber explores the phase 3 COMBI-AD melanoma trial. Could tumor mutational burden alone or in combination with interferon gamma gene signature be a prognostic factor? Medscape Oncology
Related topics: Skin Cancer, Cancer, Genetics, Oncology

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Autologous Tils Active In Refractory Melanoma

(MedPage Today) -- More than a third of patients with refractory advanced melanoma achieved durable responses to autologous tumor-infiltrating lymphocytes (TILs), according to a presentation at the American Society of Clinical Oncology (ASCO)...
Related topics: Skin Cancer, Cancer, American Society Of Clinical Oncology, Oncology

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Melanoma Risk From Biologic Therapy Remains Uncertain

THURSDAY, May 21, 2020 -- Clinically important increases in melanoma risk in patients treated with biologic therapy for common inflammatory diseases cannot be ruled out based on current evidence, according to a review published online May 20 in...
Related topics: Skin Cancer, Cancer

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Antihistamines May Help Patients With Malignant Melanoma

Can a very common allergy medicine improve survival among patients suffering from the serious skin cancer, malignant melanoma? A new study indicates that this may be the case.
Related topics: Skin Cancer, Cancer, Allergies, Oncology, Medical Research

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6-week Keytruda Safe, Effective In Melanoma

]]>(MedPage Today) -- Giving the anti-PD-1 immune checkpoint inhibitor pembrolizumab (Keytruda) at a higher dose but less often was safe and effective in patients with unresectable or metastatic melanoma, interim data from KEYNOTE 555...
Related topics: Skin Cancer, Cancer

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Targeted Tx Holiday Flops In Late-stage Melanoma

]]>(MedPage Today) -- For patients with advanced BRAF-mutant melanoma, taking a treatment holiday from BRAF/MEK inhibitors with the goal of forestalling drug resistance instead led to earlier disease progression, a randomized trial found. In the...
Related topics: Skin Cancer, Cancer

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Pfs Prolonged With Continuous Dabrafenib, Trametinib In Melanoma

WEDNESDAY, April 29, 2020 -- For patients with advanced BRAFV600E/K melanoma, continuous treatment with dabrafenib and trametinib improves progression-free survival (PFS) versus intermittent treatment, but overall survival is no different between...
Related topics: Skin Cancer, Cancer

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Triplet Succeeds In Braf-mutant Melanoma

]]>(MedPage Today) -- Adding the PD-L1-directed immunotherapy atezolizumab (Tecentriq) to a targeted combination improved progression-free survival (PFS) for advanced melanoma patients with a BRAF V600 mutation, a phase III trial showed. In over...
Related topics: Skin Cancer, Cancer, Genetics

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Missing Bap1 Gene Associated With Immunosuppressive Molecules In Uveal Melanoma

A new study reveals that tumors lacking a protein called BAP1 have an ineffective immune reaction against cancer, thus rendering immunotherapies ineffectual, particularly in uveal melanomas (UM). The researchers also discovered that when BAP1 is...
Related topics: Genetics, Skin Cancer, Cancer, Medical Research, Proteins, Oncology

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Melanoma Is Killing Fewest Americans In Decades

Advances in treatment have led to the largest yearly declines in deaths due to melanoma ever recorded for this skin cancer, results of a new study suggest.
Related topics: Skin Cancer, Cancer, Oncology, Medical Research

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Large Decrease Seen In Melanoma Mortality From 2013 To 2016

THURSDAY, March 19, 2020 -- From 2013 to 2016, there was a large decrease of 17.9 percent in melanoma mortality, according to a study published online March 19 in the American Journal of Public Health. Juliana Berk-Krauss, M.D., from the State...
Related topics: Skin Cancer, Cancer, Medical Research

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U.s. Sees Big Drop In Deaths From Melanoma

THURSDAY, March 19, 2020 -- New treatments for melanoma have dramatically reduced deaths from this often fatal skin cancer. Leaders of a new study report that the death rate from aggressive melanoma that spread to other organs plummeted 18%...
Related topics: Skin Cancer, Cancer, Oncology, Medical Research

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Crushed By A Hospital Bill? Here’s How To Stand Up For Yourself

The cost of medical treatment depleted Frances Edwards’ savings after she was diagnosed with stage 3 melanoma in October 2016 — even though she has insurance.In early 2019, she owed $6,400 in out-of-pocket charges for her first two cancer...
Related topics: Skin Cancer, Cancer, Oncology

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The Week That Wasn't: Alzheimer's Acid, Mourning & Melanoma, Preterm Epigenetics

Three medical stories that we didn't cover, explained. Medscape
Related topics: Alzheimer's Disease, Skin Cancer, Cancer

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Eureka! Scientists In Japan Train Parasitic Roundworms To ‘smell Out’ Cancer

The starting point for research into the unique new oncology detection method was man’s best friend. For over a decade now, scientists have known that canines have a nose for detecting everything from melanomas to lung, breast and bladder cancer...
Related topics: Bladder Cancer, Breast Cancer, Cancer, Lung Cancer, Oncology, Medical Research

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Cr On Anti-pd-1 Signals Long Survival In Melanoma

]]>(MedPage Today) -- Approximately four out of five patients with advanced melanoma who discontinued treatment after achieving a complete response (CR) with single-agent anti-PD-1 immunotherapy remained alive after 3 years, researchers reported...
Related topics: Skin Cancer, Cancer, Medical Research

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Banning Indoor Tanning Devices Could Save Lives And Money

Banning indoor tanning devices outright in the United States, Canada, and Europe could prevent as many as 448,000 melanomas and 9.7 million keratinocyte carcinomas, according to a recent study. Medscape Medical News
Related topics: Medical Research

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High Cutaneous Melanoma Burden Found Due To Uv Radiation

TUESDAY, Feb. 18, 2020 -- In the United States, the proportion of cases of cutaneous melanoma and age-standardized incidence rates attributable to ultraviolet (UV) radiation vary across states, but the burden is considerable in all states,...
Related topics: Skin Cancer, Cancer

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Minnesota Among States With Highest Rates Of Melanoma, Study Finds

Some of the highest rates of melanoma are in landlocked states with a relatively low ultraviolet (UV) index, including Minnesota, according to a study published Monday in the International Journal of Cancer. The study found that Utah has the highest...
Related topics: Skin Cancer, Cancer, Medical Research, Oncology

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Health Highlights: Feb. 18, 2020

Here are some of the latest health and medical news developments, compiled by the editors of HealthDay: Melanoma Cases Rising in U.S. Cases of melanoma in the United States increased 2% a year between 2005 and 2015, and will likely rise from...
Related topics: Skin Cancer, Cancer

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