Metastasis

Study Unveils The Intricate Way Two Proteins Interact To Promote Cell Movement, Metastasis

When cells in our bodies need to move—to attack an infection or heal a wound, for example—cellular proteins send and receive a cascade of signals that directs the cells to the right place at the right time. It's a process cancer cells can hijack...
Related topics: Medical Research, Proteins, Cancer, Oncology

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New Mechanism Fueling Brain Metastasis

Scientists described a novel mechanism through which astrocytes, the most abundant supporting cells in the brain, also promote cancer cell growth and metastasis in the brain.
Related topics: Brain Tumors, Cancer, Oncology

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Caught In The Act: Proteins Responsible For Metastasis

Research by Assoc. Prof. Nurhan Özlü of Koç University Department of Molecular Biology and Genetics and her team, recently published in Molecular & Cellular Proteomics, has uncovered the effects of two proteins in the transition from the...
Related topics: Proteins, Medical Research, Genetics

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The Path Of Breast-to-brain Cancer Metastasis

Scientists have discovered a signaling pathway that breast tumors exploit to metastasize to the brain.
Related topics: Breast Cancer, Brain Tumors, Cancer, Oncology, Medical Research

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Breast Cancer Cells 'stick Together' To Spread Through The Body During Metastasis

Researchers at the Johns Hopkins Kimmel Cancer Center discovered that a cell adhesion protein, E-cadherin, allows breast cancer cells to survive as they travel through the body and form new tumors, a process termed metastasis.
Related topics: Breast Cancer, Cancer, Oncology, Medical Research, Proteins

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Nanoparticle Therapy Targets Lymph Node Metastases

Metastasis, in which cancer cells break free from the primary tumor and form tumors at other sites, worsens the prognosis for many cancer patients. The lymph nodes -- glands of the immune system located throughout the body -- are typically the...
Related topics: Lymph Nodes, Cancer, Oncology

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New Alternate Cell Growth Pathway Could Lead To Better Treatments For Metastatic Cancers

A new study has found that the gene, mEAK-7, which they discovered last year, may play a key role in cancer metastasis. By comparing mEAK-7 expression levels in normal and cancer cells, they found that the gene was highly expressed in the cancer...
Related topics: Cancer, Oncology, Medical Research, Genetics

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Active Surveillance Safe For Small Renal Tumors

(MedPage Today) -- Two cases of metastasis, one cancer death among 103 patients after 4+ years of follow-up
Related topics: Cancer, Oncology

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Structure Of A 'master Switch' Controlling Cell Division

Unregulated cell division is a hallmark of cancer, and one of the key proteins involved in controlling cell division is called FoxM1. Abnormal activation of FoxM1 is a common feature of cancer cells and is correlated with poor prognosis, metastasis,...
Related topics: Cancer, Oncology, Proteins

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A New Approach To Targeting Tumors And Tracking Their Spread

The spread of malignant cells from an original tumor to other parts of the body, known as metastasis, is the main cause of cancer deaths worldwide. Early detection of tumors and metastases could significantly improve cancer survival rates....
Related topics: Cancer, Oncology

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New Review Identifies Four Hallmarks Of Cancer Metastasis

Researchers have identified four hallmarks of cancer metastasis -- when cancer has spread to different parts of the body from where it started. Metastasis is believed to be the cause of up to 90 percent of cancer deaths.
Related topics: Cancer, Oncology, Medical Research

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Chest Ct May Be Better Than Pet/ct For Hnscc Distant Metastasis Evaluation

MONDAY, March 11, 2019 -- As distant metastasis (DM) in head and neck squamous cell carcinoma (HNSCC) is a rare event, computed tomography of the chest may be more cost-effective for evaluation, according to a study recently published in Oral...
Related topics: Squamous Cell Carcinoma, Medical Research

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The Sneaky Way Estrogen Drives Brain Metastasis In Non-estrogen-dependent Breast Cancers

A new study shows that while estrogen doesn't directly affect triple-negative breast cancer cells, it can affect surrounding brain cells in ways that promote cancer cell migration and invasiveness
Related topics: Estrogen, Brain Tumors, Breast Cancer, Triple Negative Breast Cancer, Cancer, Oncology, Medical Research

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Darolutamide Slows Spread Of Castration-resistant Prostate Cancer

TUESDAY, Feb. 19, 2019 -- Metastasis-free survival is significantly longer among men with nonmetastatic, castration-resistant prostate cancer treated with darolutamide versus placebo, according to a phase 3 study published online Feb. 14 in the...
Related topics: Prostate Cancer, Cancer, Oncology, Placebo, Medical Research

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Another Win In Nonmetastatic Crpc

(MedPage Today) -- Novel drug doubles metastasis-free survival, promising for overall survival

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Acoustic Waves Can Monitor Stiffness Of Living Cells

Engineers have devised a new, non-invasive way to monitor the stiffness of single living cells, using acoustic waves. Their technique could be used to study many biological phenomena, such as cell division, programmed cell death or metastasis.
Related topics: Medical Research

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Aggregated Social Amoebae Need Physical Contact Rather Than Chemical Signals For Motivation

Collective cell migration, in which groups of cells move together with a common purpose, is important for processes ranging from wound healing to tumor metastasis. Migrating cells respond to a combination of physical cues elicited by cell-to-cell...
Related topics: Cancer

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From Microfluidics To Metastasis

Circulating tumor cells (CTCs) — an intermediate form of cancer cell between a primary and metastatic tumor cell — carry a treasure trove of information that is critical to treating cancer. Numerous engineering advancements over the years have...
Related topics: Cancer, Oncology

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Surge Protector: A Novel Approach To Suppressing Therapy-induced Tumor Growth And Recurrence

Dead and dying cancer cells killed by conventional cancer treatments paradoxically trigger inflammation that promotes tumor growth and metastasis. Researchers now describe a novel approach to suppressing chemotherapy-induced tumor growth in an...
Related topics: Cancer, Ovarian Cancer, Oncology, Medical Research, Chemotherapy

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Hindering Melanoma Metastasis With An Fda-approved Drug

A drug approved by the FDA 65 years ago for blood pressure control may aid in preventing cancer from spreading to distant organs. New research revealed that this drug disrupted formation of a fertile environment for metastasis in an animal model by...
Related topics: Skin Cancer, Melanoma, Cancer, Food And Drug Administration, Blood Pressure, Oncology, Medical Research, Fertility

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