Metastasis

Occult Brain Mets Detected In Patients With Advanced Renal Cancer

MONDAY, May 3, 2021 -- Occult brain metastasis is identified in about 4 percent of patients with metastatic renal cell carcinoma (mRCC), according to a study published in the April issue of the Journal of the National Comprehensive Cancer...
Related topics: Brain Tumors, Cancer, Oncology, Medical Research

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Membrane Around Tumors May Be Key To Preventing Metastasis

For cancer cells to metastasize, they must first break free of a tumor’s own defenses. Most tumors are sheathed in a protective “basement” membrane — a thin, pliable film that holds cancer cells in place as they grow and divide. Before...
Related topics: Cancer, Oncology

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Immune Cells In Cerebrospinal Fluid Predict Response To Immunotherapy

Immune cells accessing cerebrospinal fluid faithfully recapitulate the characteristics of cells identified in brain metastasis, and could therefore constitute novel biomarkers of response to immune-based therapies.

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When — Not What — Obese Mice Ate Reduced Breast Cancer Risk

Restricting eating to an eight-hour window, when activity is highest, decreased the risk of development, growth and metastasis of breast cancer in mouse models, report researchers at University of California San Diego School of Medicine, Moores...
Related topics: Obesity, Breast Cancer, Cancer, Oncology, Medical Research

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Changing The Perspective On The 'cinderella Of The Cytoskeleton'

SETD2, known for its involvement on gene expression, also can affect functions controlled by the cytoskeleton, such as movement, metastasis and migration, which are very important for cancer cells.
Related topics: Genetics, Cancer, Oncology

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A More Sensitive Way To Detect Circulating Tumor Cells

Breast cancer is the most frequently diagnosed cancer in women, and metastasis from the breast to other areas of the body is the leading cause of death in these patients. Detecting circulating tumor cells (CTCs) in the bloodstream could help doctors...
Related topics: Breast Cancer, Cancer, Oncology

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Risk Of Lymph Node Metastasis No Different Between Grade 1 And 2 Nets

(MedPage Today) -- Over a nearly 2-decade period, the risk for lymph node metastasis between grade 1 and grade 2 neuroendocrine tumors (NETs) of the small intestine did not appear to be statistically different, researchers reported at the 2020...
Related topics: Lymph Nodes, Cancer, Medical Research

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Daily Aspirin May Up Growth, Spread Of Cancers In Older Adults

MONDAY, Oct. 5, 2020 -- A daily, low dose of aspirin may increase the risk for progression and metastasis as well as mortality related to later-stage disease in adults aged 65 years and older who develop cancer, according to a study recently...
Related topics: Aspirin, Cancer, Oncology, Medical Research

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Benefit Of Adjuvant Dabrafenib + Trametinib Persists In Melanoma

FRIDAY, Sept. 4, 2020 -- For patients with stage III melanoma with BRAF V600E or V600K mutations, 12 months of adjuvant dabrafenib plus trametinib results in increased survival without relapse or distant metastasis at five years, according to a...
Related topics: Skin Cancer, Melanoma, Cancer, Genetics

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How Do Tumor Cells Divide In The Crowd?

Scientists studied how cancer cells are able to divide in a crowded tumor tissue and connected it to the hallmark of cancer progression and metastasis, the epithelial-mesenchymal transition (EMT).
Related topics: Cancer, Oncology

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Nanomaterials Based Strategies For Treatment Of Hypoxic Tumor

Hypoxia is a typical characteristic of most tumors, owing to the fast consumption of oxygen by tumor tissue over the supply through malformed and abnormal tumor vasculature. Hypoxia in tumor tissue promotes the probability of tumor metastasis and...
Related topics: Cancer

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Cox2 Inhibitor And Beta Blocker Combo To Reduce Crc Metastasis?

Used perioperatively, the combination significantly improved biomarkers of malignancy and resulted in a lower recurrence rate. Medscape Medical News

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Credit-card Sized Tool Provides New Insights Into How Cancer Cells Invade Host Tissues

Researchers have developed a credit-card sized tool for growing cancer cells outside the human body, which they believe will enhance their understanding of breast cancer metastasis. The device reproduces various environments within the human body...
Related topics: Breast Cancer, Cancer, Oncology, Medical Research

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Cedars-sinai To Study How Fat May Promote Cancer Spread To Liver

A diagnosis of pancreatic or colon cancer often sparks dread about the disease's likely next destination: the liver. That's because liver metastasis is a leading cause of death in these patients. A Cedars-Sinai scientific team has been awarded a...
Related topics: Medical Research, Cancer, Colon Cancer, Liver Cancer, Pancreatic Cancer, Oncology, Liver Disease

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Shift In Treatment Modalities Associated With Improved Outcomes In Uveal Melanoma Patients With...

New retrospective study indicates that the shift of treatment from systemic chemotherapies to liver-directed therapies provides survival benefits.
Related topics: Skin Cancer, Melanoma, Cancer, Medical Research

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Scientists Identify Protein That Promotes Brain Metastasis

A protein that breast, lung and other cancers use to promote their spread -- or metastasis -- to the brain, has been identified. The protein, CEMIP, will now be a focus of efforts to predict, prevent and treat brain metastases, which are a frequent...
Related topics: Proteins, Brain Tumors, Breast Cancer, Lung Cancer, Cancer, Oncology

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Zeroing In On How A Tumor Suppressor Protein Is Cast Away

Researchers have uncovered new details about several proteins implicated in tumor growth and metastasis, opening a potential avenue for the development of treatments for diseases such as breast cancer.
Related topics: Breast Cancer, Cancer, Proteins, Medical Research, Oncology

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Study Unveils The Intricate Way Two Proteins Interact To Promote Cell Movement, Metastasis

When cells in our bodies need to move—to attack an infection or heal a wound, for example—cellular proteins send and receive a cascade of signals that directs the cells to the right place at the right time. It's a process cancer cells can hijack...
Related topics: Medical Research, Proteins, Cancer, Oncology

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New Mechanism Fueling Brain Metastasis

Scientists described a novel mechanism through which astrocytes, the most abundant supporting cells in the brain, also promote cancer cell growth and metastasis in the brain.
Related topics: Brain Tumors, Cancer, Oncology

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Study Provides Insight On Targeted Therapies For Colorectal Cancer Metastasis

A new study by University of Kentucky Markey Cancer Center researchers provides new insight on targeted therapy for colorectal cancer metastasis. Published in Nature Communications, the study focused on Neuropilin-1 (NRP1), a transmembrane protein...
Related topics: Medical Research, Colon Cancer, Colorectal Cancer, Cancer, Oncology, Proteins

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