Placebo

Gabapentin Does Not Lower Pain Scores In Chronic Pelvic Pain

TUESDAY, Sept. 29, 2020 -- For women with chronic pelvic pain, gabapentin treatment does not result in significantly lower pain scores and is associated with more side effects than placebo, according to a study published online Sept. 26 in The...
Related topics: Chronic Pain, Medical Research

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We Need To Give More Thought To Informed Consent

Using a treatment without having any understanding of how it works is often thought of as unscientific, and suggesting that a placebo can help a sick patient has until now been viewed as unethical. The New England Journal of Medicine just published...

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Novel Once-weekly Insulin Shines For Type 2 Diabetes

(MedPage Today) -- A novel insulin formulation given once weekly was as safe and effective as a conventional daily insulin product for type 2 diabetes, a randomized, placebo-controlled phase II trial showed. Compared with once-daily insulin...
Related topics: Insulin, Type 2 Diabetes, Diabetes

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Covid Vaccine Placebo Isn't Always A Textbook Placebo

pla·ce·bo/pləˈsēbō/Learn to pronouncenounnoun: placebo; plural noun: placebos a harmless pill, medicine, or procedure prescribed more for the psychological benefit to the patient than for any physiological effect."his Aunt Beatrice had been...
Related topics: Vaccines, Psychology

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Adding Belimumab Improves Renal Outcome In Lupus Nephritis

THURSDAY, Sept. 17, 2020 -- The addition of belimumab versus placebo to standard therapy increases the likelihood of a primary efficacy renal response in patients with active lupus nephritis, according to a study published in the Sept. 17 issue of...
Related topics: Lupus, Medical Research

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Darolutamide Boosts Survival In Nonmetastatic Prostate Cancer

TUESDAY, Sept. 15, 2020 -- For men with nonmetastatic, castration-resistant prostate cancer, the risk for death is significantly lower for those receiving darolutamide versus placebo, according to a study published in the Sept. 10 issue of the New...
Related topics: Prostate Cancer, Cancer, Oncology, Medical Research

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Gefapixant Reduces Chronic Cough In Phase Iii Trials

(MedPage Today) -- Higher doses of the investigational oral drug gefapixant significantly decreased cough frequency compared to placebo in two highly anticipated phase III studies, but well over half of patients in both trials reported...
Related topics: Cough

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Sodium Phenylbutyrate-taurursodiol Promising For Als

THURSDAY, Sept. 3, 2020 -- For patients with amyotrophic lateral sclerosis (ALS), function declines more slowly through 24 weeks in those receiving sodium phenylbutyrate-taurursodiol versus placebo, according to a study published in the Sept. 3...
Related topics: Amyotrophic Lateral Sclerosis, Medical Research

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Empagliflozin Superior To Placebo For Heart Failure

WEDNESDAY, Sept. 2, 2020 -- Among patients with heart failure, risk for cardiovascular death or hospitalization with heart failure is lower for those receiving empagliflozin compared with placebo, according to a study published online Aug. 29 in...
Related topics: Heart Failure, Cardiology, Medical Research

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Insomnia Drug Shows Promise

(MedPage Today) -- Daridorexant, an investigational dual orexin receptor antagonist (DORA), met its primary endpoints in treating insomnia, data from the first of two phase III randomized placebo-controlled trials showed. Compared with placebo...
Related topics: Insomnia

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Evolocumab Safe And Effective In Pediatric Fh

The PCSK9 inhibitor lowered LDL cholesterol by 38% vs placebo in HAUSER-RCT, the first randomized controlled trial of one of these agents in the pediatric population. Medscape Medical News
Related topics: Cholesterol

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Cirrhosis Patients Ok For Fecal Transplant

(MedPage Today) -- Fecal microbial transplant (FMT) appeared to be safe in patients with alcohol-related liver disease, and may also reduce alcohol cravings, researchers reported. In a phase I, placebo-controlled study of 20 men with a history...
Related topics: Cirrhosis, Alcohol, Liver Disease, Medical Research

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Compared To Placebo, Vitamin D Has No Benefit For Severe Asthma Attacks, Study Finds

Contrary to earlier observational results, vitamin D supplements do not prevent severe asthma attacks in at-risk children, according to the first placebo-controlled clinical trial to test this relationship.
Related topics: Vitamins, Asthma, Medical Research, Clinical Trials

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Test Sites Quickly Attract Thousands For Covid-19 Vaccine Study

'There's a lot less risk to getting the vaccine than contracting the virus,' said Coe, 74, a retired cardiologist. 'The worst thing that can happen is if I get the placebo.' Kaiser Health News
Related topics: Vaccines, Medical Research, Virus, Virology, Cardiology

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Placebos Can Have A Powerful Effect Even If They’re Not A Secret

The potential for placebos — ‘medications’ that don’t have an active ingredient, that is — is well-known, though the exact reasons for their effectiveness remains a mystery. Generally speaking, a placebo is kept a...

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Low-dose Aspirin Prophylaxis In Elderly Ups Risk Of Serious Gi Bleeds

(MedPage Today) -- Low-dose prophylactic aspirin increased overall baseline gastrointestinal (GI) bleeding risk by approximately 60% in elderly users -- 87% for upper- and 36% for lower-GI bleeds -- according to a large randomized...
Related topics: Aspirin

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Dr. Fauci Sides With Cnn’s John Berman Over Pro-hydroxychloroquine Yale Doc: Nearly Every...

White House infectious disease honcho Dr. Anthony Fauci firmly rejected Yale epidemiologist Dr. Harvey Risch’s criticisms of randomized placebo-controlled studies of hydroxychloroquine, siding with CNN’s John Berman on his throwdown with...
Related topics: CNN, White House

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Vitamin D3 Does Not Reduce Depression Incidence, Recurrence

TUESDAY, Aug. 4, 2020 -- Treatment with vitamin D3 versus placebo does not result in a significant difference in the incidence and recurrence of depression or clinically relevant depressive symptoms or in a change in mood scores among adults aged...
Related topics: Vitamins, Depression

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Cannabidiol Studied As Potential Treatment For Cannabis Use Disorder

MONDAY, Aug. 3, 2020 -- Abstinence from cannabis is increased with daily oral doses of cannabidiol 400 mg and 800 mg versus placebo, according to a dose-finding study published online July 28 in The Lancet Psychiatry. Tom P. Freeman, Ph.D., from...
Related topics: Medical Research, The Lancet

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Canakinumab Explored As Therapy For Large-joint Osteoarthritis

MONDAY, Aug. 3, 2020 -- Inhibition of interleukin-1β (IL-1β) with canakinumab seems to reduce the incidence of total hip replacement/total knee replacement (THR/TKR) compared with placebo, according to an exploratory analysis published online...
Related topics: Arthritis, Osteoarthritis

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