Placebo

Drugmaker: Antibody Prevents Covid In Nursing Home Patients

(MedPage Today) -- Bamlanivimab, the monoclonal antibody authorized to treat less-severe cases of COVID-19, reduced the risk of contracting symptomatic disease among nursing home residents and staff in the placebo-controlled BLAZE-2 trial, said...
Related topics: Nursing

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Statin Side Effects Revisited

Patients on statins frequently report muscle pain and other side effects, but controlled studies have shown side effects are not more frequent than with placebo. Why this discrepancy? A new study sheds some light. The post Statin Side Effects...
Related topics: Medical Research

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Combination Treatment For Methamphetamine Use Disorder Shows Promise In Nih Study

A combination of two medications, injectable naltrexone and oral bupropion, was safe and effective in treating adults with moderate or severe methamphetamine use disorder in a double-blind, placebo-controlled Phase III clinical trial. The findings...
Related topics: Medical Research, Clinical Trials

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Naltrexone-bupropion Helps For Meth Addiction, But Not A Lot

(MedPage Today) -- A combination of naltrexone and bupropion was helpful in slightly reducing drug use for those struggling with methamphetamine use disorder, according to a double-blind, placebo-controlled study. During the 12-week trial, 13...
Related topics: Medical Research

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Another Crucial Coronavirus Mystery Was Just Explained

Synairgen’s SNG001 is a nebulizer containing interferon beta-1a that showed great promise in a recent Phase 2 trial. Volunteers who received the drug had greater odds of recovering from COVID-19 than placebo controls. The study did highlight a...
Related topics: Medical Research

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Positive Topline Data For Lilly's Donanemab In Early Alzheimer's

Donanemab, which targets a modified form of amyloid, slowed decline of a composite measure of cognition and function by 32% relative to placebo, topline phase 2 results show. Medscape Medical News
Related topics: Alzheimer's Disease

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The History Of Placebos & Why Doctors Should Use Them More Often

Jeremy Howick Health, A placebo can work even if a patient does not believe it is a “real” treatment. Plato’s cure for headaches involved: a certain leaf, but there was a charm to go with the remedy; and if one uttered the charm at the...

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‘covid-ized’ Science; Ethics Of Placebo; Gender-affirming Healthcare

(MedPage Today) -- "Thousands of researchers dropped whatever intellectual puzzles had previously consumed their curiosity and began working on the pandemic instead. In mere months, science became thoroughly COVID-ized," writes Ed Yong, who...
Related topics: Medical Research

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Moderna's Covid-19 Vaccine Efficacy Confirmed In Nejm Study

Among people who received mRNA-1273, the incidence of symptomatic COVID-19 was 94.1% lower than among those who received placebo, investigators report in The New England Journal of Medicine. Medscape Medical News
Related topics: Vaccines, Medical Research

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Dexamethasone Not Favored For Chronic Subdural Hematoma

WEDNESDAY, Dec. 30, 2020 -- Dexamethasone results in fewer favorable outcomes than placebo among patients with symptomatic chronic subdural hematoma, according to a study published online Dec. 16 in the New England Journal of Medicine. Peter J....
Related topics: Medical Research

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Oral Azacitidine Benefits Some Older Adults With Aml

TUESDAY, Dec. 29, 2020 -- For older patients with acute myeloid leukemia (AML) who are in remission after chemotherapy, those receiving maintenance therapy with the oral formulation of azacitidine (CC-486) versus placebo had longer overall and...
Related topics: Leukemia, Chemotherapy, Cancer

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Cgrp May Offer Both Migraine Treatment And Prevention

Oral rimegepant, the first calcitonin gene-related peptide (CGRP) receptor antagonist approved for the acute treatment of migraine, was superior to placebo in preventing migraine in a phase 2/3 trial. Medscape Medical News
Related topics: Migraine, Genetics

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Covid Vaccine Trial Placebo Group Deserves Priority Vaccination

Should individuals randomly assigned to placebo in the COVID vaccine trials be first in line for the vaccine after FDA emergency use authorization? Medscape
Related topics: Vaccines, Food And Drug Administration

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Statins And Placebo Produce Similar Side Effects

(MedPage Today) -- A clever study design at the virtual scientific sessions of the American Heart Association showed that half of the patients taking statins for LDL cholesterol-lowering that reported side effects from treatment were convinced...
Related topics: Medical Research, Cholesterol

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Anti-vaxxers Are Harassing This Poor Woman Who Just Wants Treatment For Her Fucked Up Foot

A woman who participated in the Pfizer/BioNTech trials (and received a placebo) has nothing but a bunch of death threats to show for it after an unrelated but very painful-looking foot infection, subsequent medical debt, and a whole bunch of...
Related topics: Anti Vaxxers, Pfizer

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Russia's Gamaleya Yet To Receive Authorisation To Reveal Data On Volunteers Who Got Placebo

MOSCOW (Sputnik) - The Russian drug, which became the first coronavirus vaccine in the world, previously showed efficacy of over 95% during recent trials.
Related topics: Vaccines

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Novel Monoclonal Antibody Halves Ldl Cholesterol Levels

(MedPage Today) -- Evinacumab reduced LDL cholesterol by 50% over placebo in high-risk patients with severe hypercholesterolemia whose condition was resistant to standard treatments, according to findings reported at the virtual scientific...
Related topics: Cholesterol

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Approval Of Covid-19 Vaccines Will Change Nature Of Clinical Trials

Infectious disease experts agreed with ethicists that placebo-controlled trials would no longer be ethical, but said there are valid alternatives. Medscape Medical News
Related topics: Vaccines, Clinical Trials

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Moderna Says Its Coronavirus Vaccine Is 94.5% Effective So Far

Moderna's COVID-19 vaccine is 94.5% effective according to interim data from Phase 3 trials. 30,000 Americans participated in Moderna's vaccine study, and of the 95 people that tested positive for COVID-19, 90 of them had taken the...
Related topics: Vaccines, Medical Research

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Samson Pins Most Muscle Pain With Statins On The Nocebo Effect

Some patients really do get side effects, such as muscle pain, from statins, but the trial suggests that '90% of this symptomatic burden is elicited by placebo tablets too,' researchers say. Medscape Medical News
Related topics: Medical Research

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