Placebo

Little Benefit Seen For Statin Drug In Knee Oa

(MedPage Today) -- The use of atorvastatin (Lipitor) did not reduce cartilage volume loss in patients with knee osteoarthritis (OA) over a period of 2 years, a placebo-controlled study found. Among patients randomized to receive atorvastatin...
Related topics: Cartilage, Arthritis, Osteoarthritis, Medical Research

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Can A Cox-2 Inhibitor Boost Disease-free Survival In Crc?

(MedPage Today) -- In patients with stage III colon cancer, 3 years of add-on celecoxib (Celebrex) during standard adjuvant chemotherapy did not significantly improve disease-free survival (DFS) or overall survival (OS) versus placebo, a large...
Related topics: Colon Cancer, Cancer, Oncology, Chemotherapy

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Weekly Semaglutide Bests Placebo For Greater Weight Loss

THURSDAY, April 1, 2021 -- Once-weekly subcutaneous semaglutide results in significantly greater weight loss than placebo when used as adjunctive therapy over 68 weeks in adults with overweight or obesity, according to a study published online...
Related topics: Obesity, Medical Research

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Adjuvant Nivolumab Beneficial In Esophageal, Ge Junction Cancer

THURSDAY, April 1, 2021 -- Among patients with resected esophageal or gastroesophageal junction cancer who have received neoadjuvant chemoradiotherapy, disease-free survival is significantly longer with nivolumab adjuvant therapy versus placebo,...
Related topics: Esophageal Cancer, Cancer, Oncology

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Upadacitinib Beats Placebo For Psoriatic Arthritis

WEDNESDAY, March 31, 2021 -- For patients with psoriatic arthritis, upadacitinib at a dose of 15 mg or 30 mg once daily is more effective than placebo, according to a study published in the April 1 issue of the New England Journal of...
Related topics: Psoriatic Arthritis, Arthritis, Medical Research

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The Erection Of A Placebo

When yesterday's placebo is tomorrow's treatment

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The Erection Of A Placebo

When yesterday's placebo is tomorrow's treatment

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Open-label Placebo Works As Well As Double-blind Placebo In Irritable Bowel Syndrome

In a randomized clinical trial, researchers found participants with moderate to severe irritable bowel syndrome (IBS) who were knowingly treated with a pharmacologically inactive pill -- referred to as an honest or open-label placebo -- reported...
Related topics: Irritable Bowel Syndrome, Clinical Trials, Medical Research

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Minimizing The Pesky Placebo Response In Ibs Trials

(MedPage Today) -- Pharmacological trials in irritable bowel syndrome (IBS) should include a run-in period of at least 2 weeks and dosing of no more than once or twice a day in order to minimize the pooled placebo response rate, a new...
Related topics: Irritable Bowel Syndrome

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Drug Combo Superior To Placebo For Posttraumatic Headache

THURSDAY, March 25, 2021 -- For patients with acute posttraumatic headache presenting to the emergency department, intravenous metoclopramide + diphenhydramine (M+D) is more efficacious than placebo, according to a study published online March 24...
Related topics: Medical Research

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Endo: Continuing Semaglutide Aids Weight Loss In Overweight, Obese

THURSDAY, March 25, 2021 -- For overweight and obese individuals who completed a 20-week run-in with subcutaneous semaglutide, continuing treatment is associated with a greater mean body weight change compared with switching to placebo, according...
Related topics: Obesity

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Abrocitinib Bests Placebo For Treatment Of Atopic Dermatitis

WEDNESDAY, March 24, 2021 -- For moderate-to-severe atopic dermatitis, the oral Janus kinase 1 (JAK1) inhibitor abrocitinib at 200 mg or 100 mg once daily results in significantly greater reductions in signs and symptoms versus placebo, according...
Related topics: Dermatitis

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Triple Approach To Ldl-c Pills; Gene Testing For P2y12s; Covid-19 Clot Rcts

(MedPage Today) -- Combining bempedoic acid (Nexletol), ezetimibe (Zetia), and atorvastatin cut low-density lipoprotein cholesterol by 60.5% versus placebo in a small phase II trial. (Atherosclerosis) A meta-analysis supported genetic testing...
Related topics: Genetics, Cholesterol, Atherosclerosis

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Ear Acupuncture For Procedural Pain In Neonates: More Randomized Controlled Nonsense

A recently published multicenter randomized and placebo controlled study attempted to answer the question of whether or not magnetic acupuncture beads stuck on premature baby ears reduced pain during a common screening exam. They don't. And they...
Related topics: Medical Research

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Broadly Neutralizing Antibodies Do Not Prevent Overall Hiv-1 Acquisition

THURSDAY, March 18, 2021 -- Infusion of a broadly neutralizing antibody (bnAb) does not prevent overall HIV-1 acquisition more effectively than placebo, according to a study of two trials published in the March 18 issue of the New England Journal...
Related topics: HIV, Virus, Medical Research

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Donanemab Studied In Early Symptomatic Alzheimer Disease

TUESDAY, March 16, 2021 -- For patients with early symptomatic Alzheimer disease, donanemab, which targets a modified form of deposited amyloid-ß, results in slightly less cognitive and functional decline than placebo, according to a study...
Related topics: Alzheimer's Disease, Medical Research

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The Us Has 3 Covid Vaccines—testing New Ones Is Complicated

Now that authorized versions are available, it’s tough to recruit volunteers for trials that might give them a placebo. But there are other options.
Related topics: Vaccines

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No Effect Of Low-dose Atorvastatin Found For Muscle Symptoms

WEDNESDAY, March 10, 2021 -- For individuals who reported muscle symptoms when taking statins, atorvastatin has no effect on muscle symptoms compared with placebo, according to research published online Feb. 24 in The BMJ. Emily Herrett, Ph.D.,...
Related topics: Medical Research

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Microdosing's Feel-good Benefits Might Just Be Placebo Effect

A study found no significant difference in the well-being of participants who thought they were taking mini hits of psychedelics and those who actually were.
Related topics: Medical Research

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Semaglutide May Aid Weight Loss In Obese Patients With T2dm

FRIDAY, March 5, 2021 -- Semaglutide 2.4 mg is associated with superior and clinically meaningful weight loss compared with placebo for adults with overweight or obesity and type 2 diabetes, according to a study published online March 2 in The...
Related topics: Obesity, Type 2 Diabetes, Diabetes, Medical Research

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