Stem Cells

Squishing Blood Stem Cells Could Facilitate Harvest For Transplants

How deformable cells are, and thus how stiff or squishy they are, plays an important role in retaining blood-forming stem cells in their marrow niches and thus preserving their long-term repopulation capabilities.

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How 'sleeper Cell' Cancer Stem Cells Are Maintained In Chronic Myelogenous Leukemia

Even when chronic myelogenous leukemia is in remission, 'sleeper cell,' quiescent leukemic stem cells are maintained in microenvironments in the bone marrow. This maintenance is poorly understood. Researchers now describe how niche-specific...
Related topics: Bone Cancer, Cancer, Oncology, Leukemia, Medical Research

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Using More-specific 'genetic Scissors' May Avoid Problems Associated With Gene Editing

Recent studies have suggested a potential barrier to making CRISPR gene-editing treatments a viable option for inherited blood-related disorders such as sickle cell anemia, thalassemia, and primary immunodeficiency syndromes. Stem cells may respond...
Related topics: Genetics, Anemia

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Recommendations Issued For Hsct In Multiple Myeloma

WEDNESDAY, March 20, 2019 -- A consensus statement for the use of hematopoietic stem cell transplantation (HSCT) in the treatment of multiple myeloma (MM) has been developed by Mayo Clinic physicians; the recommendations were published in the...
Related topics: Mayo Clinic

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Brazilian Scientists Produce Mini-brains With Eyes

Mini-brains, or "neural organoids," are at the cutting edge of medical research. This is the first one that's started developing eyes. Stem cells are key to the growing of organoids of various body parts. NoneOrganoids are tiny, self-organized...
Related topics: Medical Research

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Adult Stem Cells Now The ‘gold Standard’

The next time scientists and the media seek to drive public opinion on scientific issues in a partisan direction recall the Great Stem Cell Debate.
Related topics: Debate

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Oscillation In Muscle Tissue

When a muscle grows or a muscle injury heals, some of the stem cells develop into new muscle cells. A research team has now described how this process is regulated by two proteins produced in an oscillatory manner.
Related topics: Medical Research, Proteins

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Journalist's Struggle To Find Bone Marrow Match Exposes Racial Disparity In National Registry

A nationwide campaign has been launched to find a blood stem cell donor for a 29-year-old journalist who was recently diagnosed with an aggressive form of leukemia. Liyna Anwar is an Indian-American producer who used to work at StoryCorps. She...
Related topics: Blood Donation, Leukemia

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Medical News Today: Ovarian Cancer: New Drug May Prevent Recurrence

New research in mice identifies a compound that significantly improves ovarian cancer survival by targeting stem-like cancer cells.
Related topics: Ovarian Cancer, Cancer, Oncology, Medical Research

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Hematopoietic Stem Cells: Making Blood Thicker Than Water

A team revealed that Ragnase-1 is a key regulator of the self-renewal and differentiation of hematopoietic stem and progenitor cells. Knockout of this gene in mice resulted in aberrant blood cell composition and hematopoiesis, and caused...
Related topics: Genetics

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Genetically Encoded Sensor Isolates Hidden Leukemic Stem Cells

Researchers have devised a novel biosensor that can isolate and target leukemic stem cells. It can provide a prototype for precision oncology efforts to target patient-specific cells to fight the deadly disease.
Related topics: Genetics, Medical Research, Cancer, Oncology

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Starving Leukemia Cells By Targeting Amino Acids

Eliminating ASCT2 selectively stops the growth of leukemia cells, while having limited effects on healthy blood cells and hematopoetic (blood-forming) stem cells.
Related topics: Leukemia

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Embryos' Signals Take Multiple Paths

Bioscientists uncover details about how embryonic stem cells respond to the collection of signals that direct their differentiation into blood, bone and tissue. They found two critical signaling pathways are treated differently by cells.
Related topics: Embryonic Stem Cells

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Molecular Connection Between Nutrient Availability And Embryonic Growth Identified

The union of an ovule and a spermatozoon initiates a complex cell division process that will ultimately yield a new living being. In fact, all the body's cells come from embryonic stem cells that must divide in a controlled and exact fashion to give...
Related topics: Embryonic Stem Cells

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Second Patient Cleared Of Hiv After Stem-cell Therapy

A second person appears to be in remission from human immunodeficiency virus (HIV) after receiving a stem-cell transplant first used a decade ago. Experts from the Universities of Cambridge and Oxford replaced the […] The post Second Patient...
Related topics: HIV, Virus, Virology

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Treating Lymphoma With Hiv-resistant Stem Cells “cures” Another Patient

Enlarge / Artist's conception of HIV attached to a cell. (credit: Ohio State) The identification of the HIV virus ultimately led to the development of therapies that specifically target the virus' ability to make new copies of itself. These...
Related topics: Lymphoma, HIV, Virus, Virology

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Health Highlights: March 5, 2019

Here are some of the latest health and medical news developments, compiled by the editors of HealthDay: Second Man HIV-Free After Stem Cell Transplant In only the second known case worldwide, a man is free of HIV after a stem cell transplant,...
Related topics: HIV, Virus

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Second Man Seemingly Aids-free After Stem Cell Transplant

SEATTLE — A London man appears to be free of the AIDS virus after a stem cell transplant, the second success including the “Berlin patient,” doctors reported. The therapy had an early success with Timothy Ray Brown, a U.S. man treated in...
Related topics: Virus, Virology

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Second Ever Patient May Have Been Cured Of Hiv - Reports

MOSCOW (Sputnik) - Only a second person in the world diagnosed with the most common type of human immunodeficiency virus (HIV) might have been cured of the infection after receiving a stem cell transplant, CNN reported, citing a study.
Related topics: HIV, Virus, Virology, CNN, Medical Research

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2nd Man Seems To Be Free Of Aids Virus After Transplant

A London man appears to be free of the AIDS virus after a stem cell transplant, the second success including the "Berlin patient," doctors reported. The therapy had an early success with Timothy Ray Brown, a U.S. man treated in Germany who is 12...
Related topics: Virus, Virology

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