Stem Cells

Cell Therapy For Gvhd In Kids Faces Uncertain Fate In Fda Panel Review

(MedPage Today) -- WASHINGTON -- An FDA advisory panel on Thursday will decide whether to recommend approval of the investigational cellular therapy remestemcel-L for treating children with graft-versus-host disease (GVHD) following stem cell...
Related topics: Food And Drug Administration

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How Close Are We To Making Babies From Bone Marrow?

A popular Discover Magazine story from 2007 raised the possibility of using stem cells to produce human sperm. Where does the science of reproduction via stem cells stand today?
Related topics: Medical Research

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Implanted Neural Stem Cell Grafts Show Functionality In Spinal Cord Injuries

Using stem cells to restore lost functions due to spinal cord injury (SCI) has long been an ambition of scientists and doctors. Nearly 18,000 people in the United States suffer SCIs each year, with another 294,000 persons living with an SCI, usually...

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Gingivitis Ups Dementia Risk; Covid-19 Brain Fog; 'alarming' Stem Cell Tourism Complications

(MedPage Today) -- Severe gingivitis was tied to a 22% increased relative risk of future dementia. (Neurology) A blood test detected changes in gene expression in encephalopathic babies hours after they were born, identifying children who...
Related topics: Dementia, Blood Test, Genetics

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Neurologists Warn Of The Danger Of “stem Cell Tourism”

Enlarge / Skeletal stem cells are shown here in red. (credit: Noriaki Ono) Stem cells hold the promise of helping us repair tissues damaged by disease or injury. But outside of bone marrow stem cells, the practice remains largely a promise, as...

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Researchers Discover Stem Cells In Optic Nerve That Preserve Vision

Researchers have for the first time identified stem cells in the region of the optic nerve, which transmits signals from the eye to the brain. The finding presents a new theory on why the most common form of glaucoma may develop and provides...
Related topics: Medical Research, Ophthalmology, Glaucoma

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Multiomics Investigation Revealing The Characteristics Of Hiv-1-infected Cells In Vivo

A research group using HIV-1-infected cells performed 'multiomics' analyses, which are technologies recently developed to comprehensively investigate the features of biological samples.In this study, a hematopoietic stem cell-transplanted humanized...
Related topics: HIV, Virus, Medical Research

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How Airway Cells Work Together In Regeneration And Aging

Researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have identified the process by which stem cells in the airways of the lungs switch between two distinct phases — creating...
Related topics: Medical Research

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'self-eating' Process Of Stem Cells May Be The Key To New Regenerative Therapies

The self-eating process in embryonic stem cells known as chaperone-mediated autophagy (CMA) and a related metabolite may serve as promising new therapeutic targets to repair or regenerate damaged cells and organs, researchers show.
Related topics: Embryonic Stem Cells, Medical Research

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Lab Grown And Do-it-yourself: Two Emerging Routes To An Artificial Pancreas

by Steve Gillman A ‘bio-artificial’ pancreas grown in a lab with the aid of placental stem cells, and a DIY insulin-monitoring and release system are being developed to give people with insulin-dependent diabetes an alternative to...
Related topics: Insulin, Diabetes

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Skin Stem Cells Shuffle Sugars As They Age

Researchers have shown by in vitro experimentation that changes of glycans in mouse epidermal stem cells may serve as a biomarker of aging. Further, by overexpression of specific glycogenes in mouse keratinocytes, they replicated the glycome profile...
Related topics: Medical Research

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The Hair-raising Reason For Goosebumps

Researchers have discovered that the cells that cause goosebumps are also important for regulating the stem cells that regenerate hair. In the skin, the muscle that contracts to create goosebumps is necessary to bridge the sympathetic nerve's...
Related topics: Medical Research

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Turning Off “junk Dna” May Free Stem Cells To Become Neurons

For every cell in the body there comes a time when it must decide what it wants to do for the rest of its life. In an article published in the journal PNAS, National Institutes of Health researchers report for the first time that ancient viral genes...
Related topics: DNA, Genetics, Neurons, Medical Research

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Human Sperm Stem Cells Grown In Lab

Infertility affects one in seven men of reproductive age worldwide. One idea for treating male sterility is spermatogonial stem cell (SSC) therapy. In this approach, sperm stem cells in the testis are transferred to a test tube, cultured and nudged...
Related topics: Infertility, Fertility

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New Clues From Fruit Flies About The Critical Role Of Sex Hormones In Stem Cell Control

In one of the first studies addressing the role of sex hormones' impact on stem cells in the gut, scientists outline new insights showing how a steroidal sex hormone, ecdysone, drastically alters the way intestinal stem cells behave, ultimately...
Related topics: Hormones

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Hiv Remission: No Transplant Necessary

(MedPage Today) -- For over a year, a patient living with HIV has been in HIV remission following structured treatment interruption, and without the aid of a stem cell transplant or myeloablation, a researcher said here. The man, age 34, was one...
Related topics: HIV, Virus, Medical Research

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Epigenetics: What The Embryo Can Teach Us About Cell Reprogramming

Cell reprogramming provides an outstanding opportunity for the artificial generation of stem cells for regenerative medicine approaches in the clinic. As current cell reprogramming methods are low in efficiency, researchers around the globe aim to...
Related topics: Medical Research

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Stem Cell Strategies Get Compassionate Use In Covid-19

Mesenchymal stem cells are being reimagined to tackle COVID-19-associated acute respiratory distress syndrome. Medscape Medical News
Related topics: Acute Respiratory Distress Syndrome

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Epigenetics Q&a: What The Embryo Can Teach Us About Cell Reprogramming

Cell reprogramming provides an outstanding opportunity for the artificial generation of stem cells for regenerative medicine approaches in the clinic. As current cell reprogramming methods are low in efficiency, researchers around the globe aim to...
Related topics: Medical Research

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Clinical Challenges: Post-transplant Consolidation In Hodgkin's

(MedPage Today) -- Following autologous stem cell transplant, many patients with Hodgkin's lymphoma at high risk for relapse are eligible for brentuximab vedotin (Adcetris) consolidation, but as the agent moves to earlier lines of therapy,...
Related topics: Lymphoma

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