Tuberculosis

Hunting For Tb's Most Vulnerable Genes

Not every gene that's essential in tuberculosis is also vulnerable to attack. A new study ranks essential genes by vulnerability, allowing researchers to better prioritize future drug targets.
Related topics: Genetics, Medical Research

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When Stubborn Bugs Refuse To Make Drugs

An untapped trove of desirable drug-like molecules is hidden in the genomes of Streptomyces bacteria -- the same bacteria responsible for the first bacterial antibiotics to treat tuberculosis back in the 1940s. Isolating them, however, has proved...
Related topics: Bacteria, Antibiotics

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Scientists Discover A Surprising New Way That Tuberculosis Suppresses Immunity

University of Maryland researchers discovered a way that Mycobacterium tuberculosis (Mtb), the bacterium that causes tuberculosis, can cause a person's immune cells to lower their defenses. Specifically, they identified a gene in the bacterium that...
Related topics: Medical Research, Genetics

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Differentiating Strong Antibiotic Producers From Weaker Ones

An untapped trove of desirable drug-like molecules is hidden in the genomes of Streptomyces bacteria—the same bacteria responsible for the first bacterial antibiotics to treat tuberculosis back in the 1940s.
Related topics: Antibiotics, Bacteria

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Cell-analysis Technique Could Combat Tuberculosis

A new method that analyzes how individual immune cells react to the bacteria that cause tuberculosis could pave the way for new vaccine strategies against this deadly disease, and provide insights into fighting other infectious diseases around the...
Related topics: Bacteria, Vaccines

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Lower Linezolid Doses Effective Against Highly Resistant Tb

(MedPage Today) -- Various doses of the potent antibacterial linezolid (Zyvox) appeared to have similar effectiveness in clearing pulmonary tuberculosis (TB) infection in patients who have developed multidrug resistance to the infection,...
Related topics: Medical Research

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Hackensack Meridian Cdi Scientists Discover New Tuberculosis Treatment Pathway

The compound TA-C is metabolized by TB bacteria - weakening the germ from within like a 'Trojan horse' attack
Related topics: Medical Research, Bacteria, Germs

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Researchers Determine Structure Of A Bacterial Protein Complex Critical For Tuberculosis Infection

Tuberculosis is one of the top ten causes of death worldwide, infecting about one-quarter of the world's population. Although it is treatable, the rise of multidrug-resistant tuberculosis poses a major threat to global health security, and has been...
Related topics: Medical Research, Bacteria, Proteins

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Common Antibiotic Found Useful In Accelerating Recovery In Tuberculosis Patients

Researchers have discovered that the use of a common antibiotic, doxycycline, in combination with TB drug treatment, reduces the size of lung cavities and accelerates markers of lung recovery. This was done in a trial with 30 pulmonary tuberculosis...
Related topics: Antibiotics, Medical Research

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Infectious Disease And The Bitter Koch-pasteur Vaccine Rivalry

Robert Koch proved that microbes cause infectious diseases and famously identified the etiological agents of anthrax, tuberculosis, and cholera.Louis Pasteur proved that life does not spontaneously generate from non-living material, made a...
Related topics: Vaccines, Cholera

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Test Detects Childhood Tuberculosis A Year Ahead

Researchers have developed a highly sensitive blood test that can find traces of the bacteria that causes tuberculosis (TB) in infants a year before they develop the deadly disease, according to a new study.
Related topics: Blood Test, Medical Research, Bacteria

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Analysis Suggesting Measles, Polio And Tuberculosis Vaccines May Boost Immunity To Coronavirus

Institute of Human Virology at the University of Maryland School of Maryland scientists, who are also members of the Global Virus Network (GVN), a coalition comprised of human and animal virologists from 63 Centers of Excellence and 11 Affiliates in...
Related topics: Vaccines, Virus, Virology, Medical Research

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Deep-learning Ai Is Helping Google Assess Health Issues Directly In Search

At its most recent I/O event, Google announced it has a new deep-learning AI tool that can help detect, identify, and assess health issues, like skin conditions or tuberculosis (TB), more efficiently. And you can use it on your smartphone.Read This...
Related topics: Google

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Tb Immune Response Discovery Could Significantly Reduce Disease Harm

A pioneering study has discovered the presence of a harmful inflammatory protein in patients with symptomatic tuberculosis (TB). Researchers say, by targeting the IL-17 cytokine, a component produced naturally by the immune system in response to...
Related topics: Medical Research, Proteins

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Four-month Rifapentine Regimen With Moxifloxacin Noninferior For Tb

THURSDAY, May 6, 2021 -- A four-month rifapentine-based regimen containing moxifloxacin is noninferior to a standard six-month regimen for treatment of tuberculosis, according to a study published in the May 6 issue of the New England Journal of...
Related topics: Medical Research

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Tailor-made Therapy Of Multi-resistant Tuberculosis

The successful treatment of multidrug-resistant tuberculosis requires clarification in advance as to which antibiotics the pathogens are resistant to. Classic testing is very time-consuming and delays the start of therapy. Researchers have now...
Related topics: Antibiotics, Medical Research

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Starving Tuberculosis Of Sugars May Be A New Way To Fight It

Tuberculosis is a devastating disease that claims over 1.5 million lives each year. The increase in TB cases that are resistant to the current antibiotics means that novel drugs to kill Mycobacterium tuberculosis (Mtb) are urgently needed....
Related topics: Antibiotics, Medical Research

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Disrupted Movement Makes Macrophages More Lethal To Tuberculosis Bacteria

Macrophages—the front line of our immune system—protect us from infections. But in the case of the tuberculosis bacteria, this often goes wrong. The group of Annemarie Meijer from the Leiden Institute of Biology has now discovered that...
Related topics: Bacteria, Medical Research

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The Tuberculosis Pathogen Releases Its Toxin By A Novel Protein Transport System

Six years ago, researchers described the first toxin ever found for the deadly pathogen Mycobacterium tuberculosis. However, the mechanism for its secretion from the bacterium was unknown. Now, researchers describe two small Esx proteins that form...
Related topics: Proteins, Medical Research

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New Study Explains Mycobacterium Tuberculosis High Resistance To Drugs And Immunity

A consortium of researchers from Russia, Belarus, Japan, Germany and France led by a Skoltech scientist have uncovered the way in which Mycobacterium tuberculosis survives in iron-deficient conditions by utilizing rubredoxin B, a protein from a...
Related topics: Medical Research, Proteins

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