Proteins

More Protein At Breakfast, Less At Dinner May Be Key For Muscle Growth

A growing body of research indicates that staying healthy isn’t about just what you eat, but also the time of day certain foods are consumed. The latest in this collection is a study from Waseda University in Japan, where researchers have...
Related topics: Medical Research

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Reverse Optogenetic Tool Developed

A new optogenetic tool, a protein that can be controlled by light, has been characterized by researchers at Ruhr-Universität Bochum (RUB). They used an opsin—a protein that occurs in the brain and eyes—from zebrafish and introduced it into the...

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Researchers Discover That Protein Switches Functions To Regulate Dna Replication

One protein. One mechanism of action. Two biologically opposite effects.
Related topics: Scientific Discoveries, DNA, Genetics

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A Device That Cracks Milk Protein

After gaining world attention by 'unboiling' egg protein, Flinders University scientists have now used an Australian-made novel thin film microfluidic device to manipulate Beta-lactoglobulin (β-lactoglobulin), the major whey protein in cow, sheep...
Related topics: Medical Research

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New 'atlas' Charts How Antibodies Attack Spike Protein Variants

As the SARS-CoV-2 virus that causes COVID-19 continues to evolve, immunologists and infectious diseases experts are eager to know whether new variants are resistant to the human antibodies that recognized initial versions of the virus. Vaccines...
Related topics: Virus, Virology, Vaccines

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Tool Drastically Speeds The Study Of Enzymes

HT-MEK – short for High-Throughput Microfluidic Enzyme Kinetics – combines microfluidics and cell-free protein synthesis technologies to dramatically speed up the study of enzymes. (Image credit: Daniel Mokhtari) For much of human history,...

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'missing Self' Contributes To Organ Rejection After Transplantation

After kidney transplantation, natural killer cells of the recipient become active because they miss 'self' proteins on donor cells. These cells contribute to organ rejection, in addition to traditional modes of rejection involving T cells and...

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Deepmind And Embl Release The Most Complete Database Of Predicted 3d Structures Of Human Proteins

DeepMind is partnering with EMBL to make the most complete and accurate database yet of the predicted human protein structures freely and openly available to the scientific community. The AlphaFold Protein Structure Database will enable research...

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Studying Chromosomal Rearrangements In Yeast Reveals Potential Avenue For Cancer Therapy

Researchers from Osaka University have found that the attachment of a ubiquitin molecule to a protein called PCNA at the lysine 107 position causes gross chromosomal rearrangements. This lysine is located where two PCNA molecules interact, and the...
Related topics: Cancer, Oncology, Medical Research

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Gamma-secretase 'buckles Up' To Reach Its Destination

New research has uncovered the early assembly of gamma-secretase, a protein complex linked to numerous cellular processes including the development of Alzheimer's disease. In a first step, two dimeric subcomplexes are formed, which independently...
Related topics: Medical Research, Alzheimer's Disease

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Structural Biology Provides Long-sought Solution To Innate Immunity Puzzle

Researchers report the first structural confirmation that endogenous -- or self-made -- molecules can set off innate immunity in mammals via a pair of immune cell proteins called the TLR4-MD-2 receptor complex. The work has wide-ranging implications...

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Google Turns Alphafold Loose On The Entire Human Genome

Enlarge (credit: Sloan-Kettering) Just one week after Google's DeepMind AI group finally described its biology efforts in detail, the company is releasing a paper that explains how it analyzed nearly every protein encoded in the human genome and...
Related topics: Google, Genetics

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How Promiscuous Protein Droplets Regulate Immune Genes

Biochemists at Emory are achieving insights into how an important regulator of the immune system switches its function, based on its orientation and local environment. New research demonstrates that the glucocorticoid receptor (or GR) forms droplets...
Related topics: Genetics, Medical Research

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Unexpected Proteome Plasticity In Response To Persistent Temperature Rise

Common yeast are able to adapt and thrive in response to a long-term rise in temperature by changing the shape, location and function of some of their proteins. The surprising findings demonstrate the unappreciated plasticity in the molecular and...

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Unexpected Proteome Plasticity In Response To Persistent Temperature Rise

Common yeast are able to adapt and thrive in response to a long-term rise in temperature by changing the shape, location and function of some of their proteins. The surprising findings demonstrate the unappreciated plasticity in the molecular and...

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Study Innovates In Gluten-free Formulations, Creating More Palatable And Nutritious Bread

Gluten is a protein complex found in cereals such as wheat, rye and barley. It is responsible for the elastic texture of dough so that loaves and rolls can be baked into different shapes while remaining flexible and crusty. It also lengthens the...
Related topics: Medical Research

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C Is For Vitamin C -- A Key Ingredient For Immune Cell Function

Regulatory T cells (Tregs) help control inflammation and autoimmunity in the body. Unfortunately, it has proven difficult to find the right molecular ingredients to induce stable iTregs. Now a new study reports that Vitamin C and TET proteins can...
Related topics: Vitamin C, Vitamins, Medical Research

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Toward One Drug To Treat All Coronaviruses

Researchers have analyzed viral proteins across 27 coronavirus species and thousands of samples from COVID-19 patients, identifying highly conserved sequences that could make the best drug targets.
Related topics: Medical Research

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Artificially Designed Fibers Are Tougher Than Kevlar

Engineers at Washington University in St. Louis have designed a new amyloid silk hybrid protein and produced the protein in engineered bacteria. Fibers resulting from the material are stronger and tougher than natural spider silks. Spider silks are...
Related topics: Kevlar

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Sars-cov-2 Spike Mutation L452r Evades Human Immune Response And Enhances Infectivity, Researchers...

Researchers have shown that the L452R mutation of the SARS-CoV-2 spike protein, which is common to two variants (Epsilon and Delta), is involved in cellular immunity evasion via the human leukocyte antigen (HLA) A24, and enhances viral infectivity.
Related topics: Genetics, Medical Research

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